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Pathway Description
Intracellular Signalling Through Histamine H2 Receptor and Histamine
Rattus norvegicus
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-31
Last Updated: 2019-09-12
Histamine is an organic nitrogenous compound that is involved in local immune responses and it is a neurotransmitter for brain. Histamine can mediate various actions by interacting with histamine receptors (H1, H2, H3 and H4). The H2 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Intracellular Signalling Through Histamine H2 Receptor and Histamine References
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Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Feinstein PG, Schrader KA, Bakalyar HA, Tang WJ, Krupinski J, Gilman AG, Reed RR: Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10173-7. doi: 10.1073/pnas.88.22.10173.
Pubmed: 1719547
Chen J, DeVivo M, Dingus J, Harry A, Li J, Sui J, Carty DJ, Blank JL, Exton JH, Stoffel RH, et al.: A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Science. 1995 May 26;268(5214):1166-9. doi: 10.1126/science.7761832.
Pubmed: 7761832
Boran AD, Chen Y, Iyengar R: Identification of new Gbetagamma interaction sites in adenylyl cyclase 2. Cell Signal. 2011 Sep;23(9):1489-95. doi: 10.1016/j.cellsig.2011.05.002. Epub 2011 May 8.
Pubmed: 21596131
Shuntoh H, Sakamoto N, Matsuyama S, Saitoh M, Tanaka C: Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells. Biochim Biophys Acta. 1992 Jun 15;1131(2):175-80. doi: 10.1016/0167-4781(92)90073-9.
Pubmed: 1610898
Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
Pubmed: 9521123
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000335
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