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Pathway Description
Activation of PKC Through G Protein-Coupled Receptor
Rattus norvegicus
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2018-08-31
Last Updated: 2019-08-16
G protein-coupled receptors sense stimuli outside the cell and transmit signals across the plasma membrane. Activation of protein kinase C (PKC) is one of the common signaling pathways. When a class of GPCRs are activated by a ligand, they activate Gq protein to bind GTP instead of GDP. After the Gq becomes active, it activates phospholipase C (PLC) to cleave the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacyl glycerol (DAG). IP3 can bind Ins3P receptor to open calcium channel by diffusion from cytoplasm to ER. Activated calcium channel will release the calcium from ER into cytoplasm. Calcium can activate the kinase activity of PKC.
References
Activation of PKC Through G Protein-Coupled Receptor References
Mignery GA, Newton CL, Archer BT 3rd, Sudhof TC: Structure and expression of the rat inositol 1,4,5-trisphosphate receptor. J Biol Chem. 1990 Jul 25;265(21):12679-85.
Pubmed: 2165071
Danoff SK, Ferris CD, Donath C, Fischer GA, Munemitsu S, Ullrich A, Snyder SH, Ross CA: Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2951-5. doi: 10.1073/pnas.88.7.2951.
Pubmed: 1849282
Smutzer G, Zimmerman JE, Hahn CG, Ruscheinsky DD, Rodriguez A, Han LY, Arnold SE: Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue. Brain Res Mol Brain Res. 1997 Mar;44(2):347-54. doi: 10.1016/s0169-328x(96)00282-3.
Pubmed: 9073177
Lesch KP, Manji HK: Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain. Biol Psychiatry. 1992 Oct 1;32(7):549-79. doi: 10.1016/0006-3223(92)90070-g.
Pubmed: 1333286
Suh PG, Ryu SH, Moon KH, Suh HW, Rhee SG: Cloning and sequence of multiple forms of phospholipase C. Cell. 1988 Jul 15;54(2):161-9. doi: 10.1016/0092-8674(88)90548-x.
Pubmed: 3390863
Jhon DY, Lee HH, Park D, Lee CW, Lee KH, Yoo OJ, Rhee SG: Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3. J Biol Chem. 1993 Mar 25;268(9):6654-61.
Pubmed: 8454637
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Ono Y, Fujii T, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y: Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C. Nucleic Acids Res. 1988 Jun 10;16(11):5199-200. doi: 10.1093/nar/16.11.5199.
Pubmed: 3387228
Kikkawa U, Ogita K, Ono Y, Asaoka Y, Shearman MS, Fujii T, Ase K, Sekiguchi K, Igarashi K, Nishizuka Y: The common structure and activities of four subspecies of rat brain protein kinase C family. FEBS Lett. 1987 Nov 2;223(2):212-6. doi: 10.1016/0014-5793(87)80291-0.
Pubmed: 3666147
Mineo C, Ying YS, Chapline C, Jaken S, Anderson RG: Targeting of protein kinase Calpha to caveolae. J Cell Biol. 1998 May 4;141(3):601-10. doi: 10.1083/jcb.141.3.601.
Pubmed: 9566962
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000749
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