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Pathway Description
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Neurological Signaling
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-12
The 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. Serotonin is the primary ligand of the 5-HT7 receptor, which activates G(s) proteins associated with the receptor and leads to the activation of adenylyl cyclase and production of the secondary messenger cyclic adenosine monophosphate (cAMP). cAMP activates protein kinase A, phosphorylating downstream effectors that lead to specific cellular responses which mediate physiological functions such as thermoregulation, circadian rhythm, learning and memory, sleep, and potentially mood.
References
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin References
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Pubmed: 15489334
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Pubmed: 21183079
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Pubmed: 2826231
Sullivan KA, Liao YC, Alborzi A, Beiderman B, Chang FH, Masters SB, Levinson AD, Bourne HR: Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91. doi: 10.1073/pnas.83.18.6687.
Pubmed: 3092218
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Pubmed: 16141072
Uhler MD, Chrivia JC, McKnight GS: Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Nov 25;261(33):15360-3.
Pubmed: 3023318
Becker W, Kentrup H, Klumpp S, Schultz JE, Joost HG: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem. 1994 Sep 9;269(36):22586-92.
Pubmed: 8077208
Ruppert S, Cole TJ, Boshart M, Schmid E, Schutz G: Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J. 1992 Apr;11(4):1503-12.
Pubmed: 1532935
Cole TJ, Copeland NG, Gilbert DJ, Jenkins NA, Schutz G, Ruppert S: The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization. Genomics. 1992 Aug;13(4):974-82.
Pubmed: 1387109
Parker D, Ferreri K, Nakajima T, LaMorte VJ, Evans R, Koerber SC, Hoeger C, Montminy MR: Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol Cell Biol. 1996 Feb;16(2):694-703. doi: 10.1128/mcb.16.2.694.
Pubmed: 8552098
Plassat JL, Amlaiky N, Hen R: Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36.
Pubmed: 8394987
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000311
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