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Pathway Description
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-12
Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates down stream effectors that lead to a specific cellular response. This occurs though activation of the MAPK/ERK signaling cascade.
References
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine References
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Pubmed: 8157966
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Pubmed: 12693553
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000321
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