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Pathway Description
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Protein/Peptide Hormone-Mediated
Kinase Signaling
Gene Regulatory
Developmental Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-15
The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. In the ovaries, FSHRs present on granulosa cells initiate follicular development. In the testis, FSHRs present on Sertoli cells are essential for spermatogenesis. The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone References
Tena-Sempere M, Manna PR, Huhtaniemi I: Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence. Biol Reprod. 1999 Jun;60(6):1515-27. doi: 10.1095/biolreprod60.6.1515.
Pubmed: 10330114
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Pubmed: 16141072
Huhtaniemi IT, Eskola V, Pakarinen P, Matikainen T, Sprengel R: The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66. doi: 10.1016/0303-7207(92)90009-u.
Pubmed: 1459341
Rall T, Harris BA: Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma. FEBS Lett. 1987 Nov 30;224(2):365-71. doi: 10.1016/0014-5793(87)80486-6.
Pubmed: 2826231
Sullivan KA, Liao YC, Alborzi A, Beiderman B, Chang FH, Masters SB, Levinson AD, Bourne HR: Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6687-91. doi: 10.1073/pnas.83.18.6687.
Pubmed: 3092218
Kitanaka J, Wang XB, Kitanaka N, Hembree CM, Uhl GR: Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes. DNA Seq. 2001 Dec;12(5-6):345-54.
Pubmed: 11913780
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001.
Pubmed: 21183079
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P: The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan 16;30(1):143-54. doi: 10.1016/j.immuni.2008.11.006.
Pubmed: 19144319
Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S, Nakajima D, Nagase T, Ohara O, Koga H: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48. doi: 10.1093/dnares/10.1.35.
Pubmed: 12693553
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000333
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