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Pathway Description
Activation of cAMP-dependent protein kinase, PKA
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Protein/Peptide Hormone-Mediated
Kinase Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-15
cAMP dependent protein kinase is a signalling molecule, found in the nucleus and cytoplasm of cells. Cellular regulation and signal transduction in eukaryotic cells is driven by the phosphorylation of proteins. cAMP dependent protein kinase is created as an active enzyme, which is made possible by a fully phosphorylated activation loop.
References
Activation of cAMP-dependent protein kinase, PKA References
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Pubmed: 15489334
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Pubmed: 15609361
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Pubmed: 11913780
Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001.
Pubmed: 21183079
Abramowitz J, Grenet D, Birnbaumer M, Torres HN, Birnbaumer L: XLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8366-71. doi: 10.1073/pnas.0308758101. Epub 2004 May 17.
Pubmed: 15148396
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Pubmed: 19468303
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Pubmed: 10749992
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Pubmed: 11423534
Chrivia JC, Uhler MD, McKnight GS: Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase. J Biol Chem. 1988 Apr 25;263(12):5739-44.
Pubmed: 2833513
Uhler MD, Carmichael DF, Lee DC, Chrivia JC, Krebs EG, McKnight GS: Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1300-4. doi: 10.1073/pnas.83.5.1300.
Pubmed: 3456589
Uhler MD, Chrivia JC, McKnight GS: Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Nov 25;261(33):15360-3.
Pubmed: 3023318
Barradeau S, Imaizumi-Scherrer T, Weiss MC, Faust DM: Alternative 5'-exons of the mouse cAMP-dependent protein kinase subunit RIalpha gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion. FEBS Lett. 2000 Jul 7;476(3):272-6. doi: 10.1016/s0014-5793(00)01653-7.
Pubmed: 10913627
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063764
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