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Pathway Description
Nitric Oxide Signaling Pathway
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Neurological Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
Nitric oxide (NO) is a neurotransmitter that synthesized from L-arginine with faciltation of nitric oxide synthase (NOS). Nitric oxide is essential and required in central nervous system (CNS) and peripheral nervous system (PNS). Nitric oxide has several important functions such as immune responses, blood flow regulation and modulation of neurotransmission. Nitric oxide also participates in controlling sleep, adjusting body temperature, neurosecretion as well as synaptic modulation and plasticity in CNS. While in PNS, nitric oxide participates in visceral smooth muscle relaxation as well as vasodilation mediation.
References
Nitric Oxide Signaling Pathway References
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Pubmed: 1532151
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Pubmed: 15489334
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Pubmed: 1374164
Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, Yagi T, Aizawa S, Inoue Y, Sugiyama H, et al.: Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature. 1995 Jan 12;373(6510):151-5. doi: 10.1038/373151a0.
Pubmed: 7816096
Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M, Nakanishi S: Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci. 1996 Dec 15;16(24):7859-67.
Pubmed: 8987814
Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG: Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature. 1998 Dec 3;396(6710):433-9. doi: 10.1038/24790.
Pubmed: 9853749
Ogura T, Yokoyama T, Fujisawa H, Kurashima Y, Esumi H: Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system. Biochem Biophys Res Commun. 1993 Jun 30;193(3):1014-22. doi: 10.1006/bbrc.1993.1726.
Pubmed: 7686743
Silvagno F, Xia H, Bredt DS: Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle. J Biol Chem. 1996 May 10;271(19):11204-8. doi: 10.1074/jbc.271.19.11204.
Pubmed: 8626668
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. doi: 10.1126/science.1112014.
Pubmed: 16141072
Bender PK, Dedman JR, Emerson CP Jr: The abundance of calmodulin mRNAs is regulated in phosphorylase kinase-deficient skeletal muscle. J Biol Chem. 1988 Jul 15;263(20):9733-7.
Pubmed: 3384819
Kincaid RL, Giri PR, Higuchi S, Tamura J, Dixon SC, Marietta CA, Amorese DA, Martin BM: Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods. J Biol Chem. 1990 Jul 5;265(19):11312-9.
Pubmed: 2162844
Becker W, Kentrup H, Klumpp S, Schultz JE, Joost HG: Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J Biol Chem. 1994 Sep 9;269(36):22586-92.
Pubmed: 8077208
Rose-John S, Dietrich A, Marks F: Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. Gene. 1988 Dec 30;74(2):465-71. doi: 10.1016/0378-1119(88)90179-5.
Pubmed: 2469625
Megidish T, Mazurek N: A mutant protein kinase C that can transform fibroblasts. Nature. 1989 Dec 14;342(6251):807-11. doi: 10.1038/342807a0.
Pubmed: 2601739
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, Rapp UR: Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature. 1993 Jul 15;364(6434):249-52. doi: 10.1038/364249a0.
Pubmed: 8321321
Uhler MD, Chrivia JC, McKnight GS: Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Nov 25;261(33):15360-3.
Pubmed: 3023318
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063777
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