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Pathway Description
Phospholipase C Signaling Pathway
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Kinase Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-12
Phospholipase C pathways is one of the major intracellular signalling pathways regulating hormones. It functions to activate inositol lipid signalling pathways causing the hydrolysis of PIP2 by PLC to IP3 and diacylglycerol to activate protein kinase C. IP3 releases calcium from the endoplasmic reticulum. PIP3 is an important regulator of AKT signaling and downstream pathways.
References
Phospholipase C Signaling Pathway References
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Pubmed: 15489334
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Pubmed: 8687404
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Pubmed: 1714377
Voigt P, Dorner MB, Schaefer M: Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. J Biol Chem. 2006 Apr 14;281(15):9977-86. doi: 10.1074/jbc.M512502200. Epub 2006 Feb 13.
Pubmed: 16476736
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Pubmed: 16141072
Hirsch E, Wymann MP, Patrucco E, Tolosano E, Bulgarelli-Leva G, Marengo S, Rocchi M, Altruda F: Analysis of the murine phosphoinositide 3-kinase gamma gene. Gene. 2000 Oct 3;256(1-2):69-81. doi: 10.1016/s0378-1119(00)00328-0.
Pubmed: 11054537
Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM: Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 2000 Feb 11;287(5455):1040-6. doi: 10.1126/science.287.5455.1040.
Pubmed: 10669416
Yang ZZ, Tschopp O, Hemmings-Mieszczak M, Feng J, Brodbeck D, Perentes E, Hemmings BA: Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem. 2003 Aug 22;278(34):32124-31. doi: 10.1074/jbc.M302847200. Epub 2003 Jun 3.
Pubmed: 12783884
Kang ES, Han D, Park J, Kwak TK, Oh MA, Lee SA, Choi S, Park ZY, Kim Y, Lee JW: O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res. 2008 Jul 1;314(11-12):2238-48. doi: 10.1016/j.yexcr.2008.04.014. Epub 2008 May 9.
Pubmed: 18570920
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN: Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene. 1993 Mar;8(3):745-54.
Pubmed: 8437858
Coppola J, Bryant S, Koda T, Conway D, Barbacid M: Mechanism of activation of the vav protooncogene. Cell Growth Differ. 1991 Feb;2(2):95-105.
Pubmed: 2069873
Adams JM, Houston H, Allen J, Lints T, Harvey R: The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. Oncogene. 1992 Apr;7(4):611-8.
Pubmed: 1565462
Rose-John S, Dietrich A, Marks F: Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblasts. Gene. 1988 Dec 30;74(2):465-71. doi: 10.1016/0378-1119(88)90179-5.
Pubmed: 2469625
Megidish T, Mazurek N: A mutant protein kinase C that can transform fibroblasts. Nature. 1989 Dec 14;342(6251):807-11. doi: 10.1038/342807a0.
Pubmed: 2601739
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, Rapp UR: Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature. 1993 Jul 15;364(6434):249-52. doi: 10.1038/364249a0.
Pubmed: 8321321
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063783
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