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Pathway Description
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Neurological Signaling
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-12
The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS. Peripheral receptors have important roles in the function of many organ responses (alimentary tract, urinary bladder, heart, and adrenal gland). Alimentary tract receptors have a role in smooth muscle tone, mucosal electrolyte secretion, and the peristaltic reflex. Urinary bladder receptors control cholinergic/purinergic transmission. Atrial heart receptors produce positive inotropy and tachycardia that can precipitate arrhythmias. This receptor is also thought to have roles in anxiety, appetite, GI motility, learning, memory, mood, and respiration. The 5-HT4 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin References
Volkel H, Beitz E, Klumpp S, Schultz JE: Cloning and expression of a bovine adenylyl cyclase type VII specific to the retinal pigment epithelium. FEBS Lett. 1996 Jan 15;378(3):245-9. doi: 10.1016/0014-5793(95)01470-5.
Pubmed: 8557110
Nukada T, Tanabe T, Takahashi H, Noda M, Hirose T, Inayama S, Numa S: Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.
Pubmed: 3080331
Robishaw JD, Russell DW, Harris BA, Smigel MD, Gilman AG: Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1251-5. doi: 10.1073/pnas.83.5.1251.
Pubmed: 3081893
Robishaw JD, Smigel MD, Gilman AG: Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem. 1986 Jul 25;261(21):9587-90.
Pubmed: 3015900
Showers MO, Maurer RA: A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Dec 15;261(35):16288-91.
Pubmed: 3023347
Wiemann S, Kinzel V, Pyerin W: Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1991 Mar 15;266(8):5140-6.
Pubmed: 2002051
Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
Pubmed: 9521123
Willems L, Kettmann R, Chen G, Portetelle D, Burny A, Derse D: Nucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA. DNA Seq. 1991;1(6):415-7.
Pubmed: 1837490
Willems L, Kettmann R, Chen G, Portetelle D, Burny A, Derse D: A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. J Virol. 1992 Feb;66(2):766-72.
Pubmed: 1309910
Adam E, Kerkhofs P, Mammerickx M, Kettmann R, Burny A, Droogmans L, Willems L: Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo. J Virol. 1994 Sep;68(9):5845-53.
Pubmed: 8057465
Einspanier R, Gabler C, Kettler A, Kloas W: Characterization and localization of beta2-adrenergic receptors in the bovine oviduct: indication for progesterone-mediated expression. Endocrinology. 1999 Jun;140(6):2679-84. doi: 10.1210/endo.140.6.6701.
Pubmed: 10342858
Morishita R, Nakayama H, Isobe T, Matsuda T, Hashimoto Y, Okano T, Fukada Y, Mizuno K, Ohno S, Kozawa O, et al.: Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. J Biol Chem. 1995 Dec 8;270(49):29469-75. doi: 10.1074/jbc.270.49.29469.
Pubmed: 7493986
Fong HK, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, Doolittle RF, Simon MI: Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2162-6. doi: 10.1073/pnas.83.7.2162.
Pubmed: 3083416
Sugimoto K, Nukada T, Tanabe T, Takahashi H, Noda M, Minamino N, Kangawa K, Matsuo H, Hirose T, Inayama S, et al.: Primary structure of the beta-subunit of bovine transducin deduced from the cDNA sequence. FEBS Lett. 1985 Oct 28;191(2):235-40. doi: 10.1016/0014-5793(85)80015-6.
Pubmed: 2414128
Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T: Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003 Feb 28;278(9):7220-6. doi: 10.1074/jbc.M210304200. Epub 2002 Dec 16.
Pubmed: 12486123
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000309
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