PathBank

Pathway Description

Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone

Bos taurus

Category:

Protein Pathway

Sub-Categories:

Protein/Peptide Hormone-Mediated

Kinase Signaling

Gene Regulatory

Developmental Signaling

Cellular Response

Created: 2018-08-31

Last Updated: 2019-09-15

The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. In the ovaries, FSHRs present on granulosa cells initiate follicular development. In the testis, FSHRs present on Sertoli cells are essential for spermatogenesis. The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response.

References

Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone References

Houde A, Lambert A, Saumande J, Silversides DW, Lussier JG: Structure of the bovine follicle-stimulating hormone receptor complementary DNA and expression in bovine tissues. Mol Reprod Dev. 1994 Oct;39(2):127-35. doi: 10.1002/mrd.1080390202.

Pubmed: 7826612

Nukada T, Tanabe T, Takahashi H, Noda M, Hirose T, Inayama S, Numa S: Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.

Pubmed: 3080331

Robishaw JD, Russell DW, Harris BA, Smigel MD, Gilman AG: Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1251-5. doi: 10.1073/pnas.83.5.1251.

Pubmed: 3081893

Robishaw JD, Smigel MD, Gilman AG: Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem. 1986 Jul 25;261(21):9587-90.

Pubmed: 3015900

Fong HK, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, Doolittle RF, Simon MI: Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2162-6. doi: 10.1073/pnas.83.7.2162.

Pubmed: 3083416

Sugimoto K, Nukada T, Tanabe T, Takahashi H, Noda M, Minamino N, Kangawa K, Matsuo H, Hirose T, Inayama S, et al.: Primary structure of the beta-subunit of bovine transducin deduced from the cDNA sequence. FEBS Lett. 1985 Oct 28;191(2):235-40. doi: 10.1016/0014-5793(85)80015-6.

Pubmed: 2414128

Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T: Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. J Biol Chem. 2003 Feb 28;278(9):7220-6. doi: 10.1074/jbc.M210304200. Epub 2002 Dec 16.

Pubmed: 12486123

Morishita R, Nakayama H, Isobe T, Matsuda T, Hashimoto Y, Okano T, Fukada Y, Mizuno K, Ohno S, Kozawa O, et al.: Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. J Biol Chem. 1995 Dec 8;270(49):29469-75. doi: 10.1074/jbc.270.49.29469.

Pubmed: 7493986

Volkel H, Beitz E, Klumpp S, Schultz JE: Cloning and expression of a bovine adenylyl cyclase type VII specific to the retinal pigment epithelium. FEBS Lett. 1996 Jan 15;378(3):245-9. doi: 10.1016/0014-5793(95)01470-5.

Pubmed: 8557110

Showers MO, Maurer RA: A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1986 Dec 15;261(35):16288-91.

Pubmed: 3023347

Wiemann S, Kinzel V, Pyerin W: Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1991 Mar 15;266(8):5140-6.

Pubmed: 2002051

Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.

Pubmed: 9521123

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0000333

	Adenosine triphosphate
	cAMP
	Guanosine diphosphate
	Guanosine triphosphate
	Magnesium
	Phosphate
	Pyrophosphate

	Adenylate cyclase type 7
	cAMP-dependent protein kinase catalytic subunit beta
	Cyclic AMP-responsive element-binding protein 1
	Follicle-stimulating hormone receptor
	Follitropin subunit beta
	Glycoprotein hormones alpha chain
	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
	Unknown

		Adenosine triphosphate
		cAMP
		Guanosine diphosphate
		Guanosine triphosphate
		Magnesium
		Phosphate
		Pyrophosphate

		Adenylate cyclase type 7
		cAMP-dependent protein kinase catalytic subunit beta
		Cyclic AMP-responsive element-binding protein 1
		Follicle-stimulating hormone receptor
		Follitropin subunit beta
		Glycoprotein hormones alpha chain
		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
		Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
		Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
		Unknown

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Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone

Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone References