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Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-2 Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-2 AKT1 Inositol 1,4,5- trisphosphate receptor type 1 Gαs Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 LPAR1 LPAR1 Inositol 1,4,5- trisphosphate Ca+ Ca+ ATP cAMP PPi H2O Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB PLC 1,2-diacyl- sn-glycerol PKC Lysophosphatidic acid phosphatidylinositol 4,5- bisphosphate Gαi/o Gαq/11 Lysophosphatidic acid Phospholipid Biosynthesis Magnesium Calcium GTP GTP GDP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane
Endoplasmic Reticulum GNG2 GNG2 AKT1 ITPR1 GNAS GNB1 GNB1 LPAR1 LPAR1 Inositol 1,4,5- trisphosphate Calcium Calcium Adenosine triphosphate cAMP Pyrophosphate Water Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB PLC 1,2-diacyl- sn-glycerol PKC Lysophosphatidic acid phosphatidylinositol 4,5- bisphosphate Gαi/o Gαq/11 Lysophosphatidic acid Phospholipid Biosynthesis Guanosine triphosphate Guanosine triphosphate Guanosine diphosphate Guanosine triphosphate
GNG2 GNG2 AKT1 ITPR1 GNAS GNB1 GNB1 LPAR1 LPAR1 Inotp Ca+ Ca+ ATP cAMP PPi H2O AC Ras RAF MEK MAPK PI3K Rac NF-κB PLC 12DSG PKC LA P45B Gαi/o Gαq/11 LA PW000048 Mg2+ Ca2+ GTP GTP GDP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane
Endoplasmic Reticulum GNG2 GNG2 AKT1 ITPR1 GNAS GNB1 GNB1 LPAR1 LPAR1 Inotp Ca2+ Ca2+ ATP cAMP Ppi H2O AC Ras RAF MEK MAPK PI3K Rac NF-κB PLC 12DSG PKC LA P45B Gαi/o Gαq/11 LA PW000048 GTP GTP GDP GTP