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Pathway Description
Apoptotic DNA Fragmentation and Tissue Homeostasis
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Apoptosis Signaling
Transport/Degradation
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
Apoptotic endonucleases degrade chromosomal DNA during programmed cell death. ICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis. Once released from the mitochondrial intermembrane space, EndoG activity is caspase independent.
References
Apoptotic DNA Fragmentation and Tissue Homeostasis References
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Cote J, Ruiz-Carrillo A: Primers for mitochondrial DNA replication generated by endonuclease G. Science. 1993 Aug 6;261(5122):765-9. doi: 10.1126/science.7688144.
Pubmed: 7688144
Moos M Jr, Nguyen NY, Liu TY: Reproducible high yield sequencing of proteins electrophoretically separated and transferred to an inert support. J Biol Chem. 1988 May 5;263(13):6005-8.
Pubmed: 3360771
Gerschenson M, Houmiel KL, Low RL: Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria. Nucleic Acids Res. 1995 Jan 11;23(1):88-97. doi: 10.1093/nar/23.1.88.
Pubmed: 7870594
Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A: RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity. 2010 Feb;43(1):103-10. doi: 10.3109/08916930903384591.
Pubmed: 20014975
Joshi SR, Sarpong YC, Peterson RC, Scovell WM: Nucleosome dynamics: HMGB1 relaxes canonical nucleosome structure to facilitate estrogen receptor binding. Nucleic Acids Res. 2012 Nov 1;40(20):10161-71. doi: 10.1093/nar/gks815. Epub 2012 Aug 31.
Pubmed: 22941653
Li G, Liang X, Lotze MT: HMGB1: The Central Cytokine for All Lymphoid Cells. Front Immunol. 2013 Mar 20;4:68. doi: 10.3389/fimmu.2013.00068. eCollection 2013.
Pubmed: 23519706
Christen T, Bischoff M, Hobi R, Kuenzle CC: High mobility group proteins 1 and 2 bind preferentially to brominated poly(dG-dC).poly(dG-dC) in the Z-DNA conformation but not to other types of Z-DNA. FEBS Lett. 1990 Jul 2;267(1):139-41. doi: 10.1016/0014-5793(90)80308-6.
Pubmed: 2365081
Das D, Peterson RC, Scovell WM: High mobility group B proteins facilitate strong estrogen receptor binding to classical and half-site estrogen response elements and relax binding selectivity. Mol Endocrinol. 2004 Nov;18(11):2616-32. doi: 10.1210/me.2004-0125. Epub 2004 Jul 15.
Pubmed: 15256536
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063772
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