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BTG Family Proteins and Cell Cycle Regulation
Last Updated: 2019-08-16
BTG Family Member-2 (BTG2) is endowed with antiproliferative activity. The expression of BTG2 in cycling cells induces accumulation of hypophosphorylated, growth-inhibitory forms of Retinoblastoma protein(Rb) and lead to G1 arrest through impairment of DNA synthesis. Rb is a nuclear phosphoprotein whose phosphorylation state oscillates regularly during the cell cycle. Hypophosphorylated Rb associates with members of the E2F family of transcription factors, impairing their activity and leading to a cell cycle block in G1. Conversely, the phosphorylation of Rb inactivates its growth suppression activity by freeing E2F molecules, thus enabling them to transactivate genes required for the progression of the cell into S phase and the remainder of the cell cycle. Cyclin-dependent kinases (CDKs) are the molecules responsible for Rb phosphorylation and its consequent inactivation.
BTG Family Proteins and Cell Cycle Regulation References
Halley C, Courtois Y, Laurent M: Nucleotide sequence of bovine acidic fibroblast growth factor cDNA. Nucleic Acids Res. 1988 Nov 25;16(22):10913. doi: 10.1093/nar/16.22.10913.Pubmed: 3205724
Alterio J, Halley C, Brou C, Soussi T, Courtois Y, Laurent M: Characterization of a bovine acidic FGF cDNA clone and its expression in brain and retina. FEBS Lett. 1988 Dec 19;242(1):41-6. doi: 10.1016/0014-5793(88)80981-5.Pubmed: 2849564
Burgess WH, Mehlman T, Marshak DR, Fraser BA, Maciag T: Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7216-20. doi: 10.1073/pnas.83.19.7216.Pubmed: 3532107
Elduque C, Laurent P, Hayes H, Rodellar C, Leveziel H, Zaragoza P: Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization. Cytogenet Cell Genet. 1997;77(3-4):306-7. doi: 10.1159/000134604.Pubmed: 9284944
Meier R, Becker-Andre M, Gotz R, Heumann R, Shaw A, Thoenen H: Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF. EMBO J. 1986 Jul;5(7):1489-93.Pubmed: 2427334
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.Pubmed: 16305752
Bostrom K, Tintut Y, Kao SC, Stanford WP, Demer LL: HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells. J Cell Biochem. 2000 May;78(2):210-21.Pubmed: 10842316
Dequiedt F, Willems L, Burny A, Kettmann R: Nucleotide sequence of the bovine P53 tumor-suppressor cDNA. DNA Seq. 1995;5(4):261-4.Pubmed: 7626789
Komori H, Ishiguro N, Horiuchi M, Shinagawa M, Aida Y: Predominant p53 mutations in enzootic bovine leukemic cell lines. Vet Immunol Immunopathol. 1996 Jun 15;52(1-2):53-63.Pubmed: 8807776
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.Pubmed: 19393038
This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063773
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