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Pathway Description
Ion Channels and Their Functional Role in Vascular Endothelium
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Transport/Degradation
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
In endothelial cell, ion channels such as agonist-activated nonselective Ca(2+)-permeable cation channels, cyclic nucleotide-activated nonselective cation channels, and store-operated Ca(2+) channels or capacitative Ca(2+) entry are controlled by intracellular Ca(2+) signals. Some of the channels are expressed by trp gene family. Ca(2+) entry is also controlled by large-conductance Ca(2+)-dependent BK(Ca) channels (slo), inwardly rectifying K(+) channels, Ca(2+)-activated Cl(-) channel and volume-regulated anion channel (VRAC). VRAC channels can also transport organic osmolytes and amino acid.
References
Ion Channels and Their Functional Role in Vascular Endothelium References
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Lamas S, Marsden PA, Li GK, Tempst P, Michel T: Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6348-52. doi: 10.1073/pnas.89.14.6348.
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Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ: Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 1992 Nov;90(5):2092-6. doi: 10.1172/JCI116092.
Pubmed: 1385480
Sessa WC, Harrison JK, Barber CM, Zeng D, Durieux ME, D'Angelo DD, Lynch KR, Peach MJ: Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem. 1992 Aug 5;267(22):15274-6.
Pubmed: 1379225
Koesling D, Harteneck C, Humbert P, Bosserhoff A, Frank R, Schultz G, Bohme E: The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. Homology between the two subunits of the enzyme. FEBS Lett. 1990 Jun 18;266(1-2):128-32. doi: 10.1016/0014-5793(90)81523-q.
Pubmed: 1973124
Liu Y, Ruoho AE, Rao VD, Hurley JH: Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13414-9. doi: 10.1073/pnas.94.25.13414.
Pubmed: 9391039
Koesling D, Herz J, Gausepohl H, Niroomand F, Hinsch KD, Mulsch A, Bohme E, Schultz G, Frank R: The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. FEBS Lett. 1988 Oct 24;239(1):29-34. doi: 10.1016/0014-5793(88)80539-8.
Pubmed: 2903071
Wedel B, Humbert P, Harteneck C, Foerster J, Malkewitz J, Bohme E, Schultz G, Koesling D: Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2592-6. doi: 10.1073/pnas.91.7.2592.
Pubmed: 7908439
Zhao Y, Schelvis JP, Babcock GT, Marletta MA: Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand. Biochemistry. 1998 Mar 31;37(13):4502-9. doi: 10.1021/bi972686m.
Pubmed: 9521770
Philipp S, Trost C, Warnat J, Rautmann J, Himmerkus N, Schroth G, Kretz O, Nastainczyk W, Cavalie A, Hoth M, Flockerzi V: TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-like channels in adrenal cells. J Biol Chem. 2000 Aug 4;275(31):23965-72. doi: 10.1074/jbc.M003408200.
Pubmed: 10816590
Philipp S, Cavalie A, Freichel M, Wissenbach U, Zimmer S, Trost C, Marquart A, Murakami M, Flockerzi V: A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J. 1996 Nov 15;15(22):6166-71.
Pubmed: 8947038
Freichel M, Wissenbach U, Philipp S, Flockerzi V: Alternative splicing and tissue specific expression of the 5' truncated bCCE 1 variant bCCE 1delta514. FEBS Lett. 1998 Feb 6;422(3):354-8. doi: 10.1016/s0014-5793(98)00041-6.
Pubmed: 9498815
Wernet W, Flockerzi V, Hofmann F: The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. FEBS Lett. 1989 Jul 17;251(1-2):191-6. doi: 10.1016/0014-5793(89)81453-x.
Pubmed: 2546820
Ruth P, Pfeifer A, Kamm S, Klatt P, Dostmann WR, Hofmann F: Identification of the amino acid sequences responsible for high affinity activation of cGMP kinase Ialpha. J Biol Chem. 1997 Apr 18;272(16):10522-8. doi: 10.1074/jbc.272.16.10522.
Pubmed: 9099696
Takio K, Wade RD, Smith SB, Krebs EG, Walsh KA, Titani K: Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. Biochemistry. 1984 Aug 28;23(18):4207-18. doi: 10.1021/bi00313a030.
Pubmed: 6091741
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063778
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