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Zinc Ras-related protein Rap-1b RAS guanyl- releasing protein 2 Ras-related protein Rap-1A Active breakpoint cluster region-related protein Cell division control protein 42 homolog Ras-related C3 botulinum toxin substrate 1 RAC-alpha serine/threonine- protein kinase Proto-oncogene vav BCL2 associated agonist of cell death Caspase-3 Forkhead box protein O1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Apoptosis regulator Bcl-2 Unknown Phospholipase D2 Ras-related C3 botulinum toxin substrate 1 RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 1 ETS translocation variant 1 Pi Pi Pi PI3K PIP3 NF-κB PIP2 PC Phosphatidic Acid ERK 1/2 pathway Caspase Cascade Pathway AKT Pathway Anti-apoptotic Apoptosis Fas ligand expression Expression of anti-apoptotic genes Rac GDP-GTP exchange factors (eg. Vav and Sos1 Cytoplasm
RAP1B RASGRP2 RAP1A ABR CDC42 RAC1 AKT1 VAV1 BAD CASP3 FOXO1 CHUK BCL2 Unknown PLD2 RAC1 RAF1 MAP2K6 MAPK1 ETV1 Phosphate Phosphate Phosphate PI3K PIP3 NF-κB PIP2 PC Phosphatidic Acid ERK 1/2 pathway Caspase Cascade Pathway
Zinc RAP1B RASGRP2 RAP1A ABR CDC42 RAC1 AKT1 VAV1 BAD CASP3 FOXO1 CHUK BCL2 PLD2 RAC1 RAF1 MAP2K6 MAPK1 ETV1 Pi Pi Pi PI3K PIP3 NF-κB PIP2 PC PA ER 1/ p Ca Ca P AKT Pathway Anti-apoptotic Apoptosis Fas ligand expression Expression of anti-apoptotic genes Rac GDP-GTP exchange factors (eg. Vav and Sos1 Cytoplasm
RAP1B RASGRP2 RAP1A ABR CDC42 RAC1 AKT1 VAV1 BAD CASP3 FOXO1 CHUK BCL2 PLD2 RAC1 RAF1 MAP2K6 MAPK1 ETV1 Pi Pi Pi PI3K PIP3 NF-κB PIP2 PC PA ER 1/ p Ca Ca P