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Pathway Description
Cadmium Induces DNA Synthesis and Proliferation in Macrophages
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Immunological
Disease
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
Cadmium (Cd(2+)) exposure increases the risk of cancer in humans and animals. Humans may come into contact with cadmium when smoking and ingesting contaminated food. This will increase the risk of lung cancer and prostate cancer. In the millimolar range, cadmium will inhibit cell growth. Cadmium induces DNA synthesis and proliferation and affects signal transduction and mobilization in macrophages. At micromolar concentrations, cadmium significantly increased cell division as judged by thymidine uptake and cell counts. Activating this pathway will increase the availability of the transcription factor NF(kappa)B and will activate the early genes c-fos and c-myc.
References
Cadmium Induces DNA Synthesis and Proliferation in Macrophages References
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Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A: Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science. 1986 Aug 22;233(4766):859-66. doi: 10.1126/science.3755548.
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Matsui Y, Kikuchi A, Kawata M, Kondo J, Teranishi Y, Takai Y: Molecular cloning of smg p21B and identification of smg p21 purified from bovine brain and human platelets as smg p21B. Biochem Biophys Res Commun. 1990 Jan 30;166(2):1010-6. doi: 10.1016/0006-291x(90)90911-6.
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Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166.
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Yoo SH, Oh YS, Kang MK, Huh YH, So SH, Park HS, Park HY: Localization of three types of the inositol 1,4,5-trisphosphate receptor/Ca(2+) channel in the secretory granules and coupling with the Ca(2+) storage proteins chromogranins A and B. J Biol Chem. 2001 Dec 7;276(49):45806-12. doi: 10.1074/jbc.M107532200. Epub 2001 Oct 2.
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Pubmed: 10724174
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063805
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