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Pathway Description
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Neurological Signaling
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-13
The 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. Serotonin is the primary ligand of the 5-HT7 receptor, which activates G(s) proteins associated with the receptor and leads to the activation of adenylyl cyclase and production of the secondary messenger cyclic adenosine monophosphate (cAMP). cAMP activates protein kinase A, phosphorylating downstream effectors that lead to specific cellular responses which mediate physiological functions such as thermoregulation, circadian rhythm, learning and memory, sleep, and potentially mood.
References
Excitatory Neural Signalling Through 5-HTR 7 and Serotonin References
Feinstein PG, Schrader KA, Bakalyar HA, Tang WJ, Krupinski J, Gilman AG, Reed RR: Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10173-7. doi: 10.1073/pnas.88.22.10173.
Pubmed: 1719547
Chen J, DeVivo M, Dingus J, Harry A, Li J, Sui J, Carty DJ, Blank JL, Exton JH, Stoffel RH, et al.: A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Science. 1995 May 26;268(5214):1166-9. doi: 10.1126/science.7761832.
Pubmed: 7761832
Boran AD, Chen Y, Iyengar R: Identification of new Gbetagamma interaction sites in adenylyl cyclase 2. Cell Signal. 2011 Sep;23(9):1489-95. doi: 10.1016/j.cellsig.2011.05.002. Epub 2011 May 8.
Pubmed: 21596131
Itoh H, Kozasa T, Nagata S, Nakamura S, Katada T, Ui M, Iwai S, Ohtsuka E, Kawasaki H, Suzuki K, et al.: Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3776-80. doi: 10.1073/pnas.83.11.3776.
Pubmed: 3086867
Jones DT, Reed RR: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem. 1987 Oct 15;262(29):14241-9.
Pubmed: 2820999
Crawford JA, Mutchler KJ, Sullivan BE, Lanigan TM, Clark MS, Russo AF: Neural expression of a novel alternatively spliced and polyadenylated Gs alpha transcript. J Biol Chem. 1993 May 5;268(13):9879-85.
Pubmed: 8486667
Shuntoh H, Sakamoto N, Matsuyama S, Saitoh M, Tanaka C: Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells. Biochim Biophys Acta. 1992 Jun 15;1131(2):175-80. doi: 10.1016/0167-4781(92)90073-9.
Pubmed: 1610898
Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
Pubmed: 9521123
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Kitamura K, Mizuno Y, Sasaki A, Yasui A, Tsuiki S, Kikuchi K: Molecular cloning and sequence analysis of cDNA for the catalytic subunit 1 alpha of rat kidney type 1 protein phosphatase, and detection of the gene expression at high levels in hepatoma cells and regenerating livers as compared to rat livers. J Biochem. 1991 Feb;109(2):307-10.
Pubmed: 1650776
Sasaki K, Shima H, Kitagawa Y, Irino S, Sugimura T, Nagao M: Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Jpn J Cancer Res. 1990 Dec;81(12):1272-80. doi: 10.1111/j.1349-7006.1990.tb02690.x.
Pubmed: 2177460
da Cruz e Silva EF, Fox CA, Ouimet CC, Gustafson E, Watson SJ, Greengard P: Differential expression of protein phosphatase 1 isoforms in mammalian brain. J Neurosci. 1995 May;15(5 Pt 1):3375-89.
Pubmed: 7751917
Gonzalez GA, Yamamoto KK, Fischer WH, Karr D, Menzel P, Biggs W 3rd, Vale WW, Montminy MR: A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature. 1989 Feb 23;337(6209):749-52. doi: 10.1038/337749a0.
Pubmed: 2521922
Short ML, Manohar CF, Furtado MR, Ghadge GD, Wolinsky SM, Thimmapaya B, Jungmann RA: Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. Nucleic Acids Res. 1991 Aug 11;19(15):4290. doi: 10.1093/nar/19.15.4290.
Pubmed: 1831258
Sheng M, Thompson MA, Greenberg ME: CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science. 1991 Jun 7;252(5011):1427-30. doi: 10.1126/science.1646483.
Pubmed: 1646483
Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, Schwartz JC: Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8547-51. doi: 10.1073/pnas.90.18.8547.
Pubmed: 8397408
Meyerhof W, Obermuller F, Fehr S, Richter D: A novel rat serotonin receptor: primary structure, pharmacology, and expression pattern in distinct brain regions. DNA Cell Biol. 1993 Jun;12(5):401-9. doi: 10.1089/dna.1993.12.401.
Pubmed: 8517926
Lovenberg TW, Baron BM, de Lecea L, Miller JD, Prosser RA, Rea MA, Foye PE, Racke M, Slone AL, Siegel BW, et al.: A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58. doi: 10.1016/0896-6273(93)90149-l.
Pubmed: 8398139
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000311
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