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Pathway Description
Fc Epsilon Receptor I Signaling in Mast Cells
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Immunological
Cytokine Signaling
Kinase Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-13
Fc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies. The antigens of allergens bind to IgE antibodies, which then interact with Fc epsilon RIs on the surface of mast cells. This activates the mast cells and results in degranulation, a process by which preformed granules containing histamine, proteoglycans, and serine proteases, are released. Activated mast cells also synthesize and secrete lipid-derived mediators (such as prostaglandins, leukotrienes, and platelet-activating factor) and cytokines (notably tumor necrosis factor-alpha, interleukin-4, and interleukin-5). The release of these compounds results in the inflammatory response.
References
Fc Epsilon Receptor I Signaling in Mast Cells References
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This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000358
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