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Pathway Description
Apoptotic DNA Fragmentation and Tissue Homeostasis
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Apoptosis Signaling
Transport/Degradation
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
Apoptotic endonucleases degrade chromosomal DNA during programmed cell death. ICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis. Once released from the mitochondrial intermembrane space, EndoG activity is caspase independent.
References
Apoptotic DNA Fragmentation and Tissue Homeostasis References
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Pubmed: 22673903
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Pubmed: 3038878
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Pubmed: 19754428
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Kawano S, Miyaji M, Ichiyasu S, Tsutsui KM, Tsutsui K: Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U). J Biol Chem. 2010 Aug 20;285(34):26451-60. doi: 10.1074/jbc.M110.112979. Epub 2010 Jun 16.
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Merenmies J, Pihlaskari R, Laitinen J, Wartiovaara J, Rauvala H: 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. J Biol Chem. 1991 Sep 5;266(25):16722-9.
Pubmed: 1885601
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063772
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