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Pathway Description
Nitric Oxide Signaling Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Neurological Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-08-16
Nitric oxide (NO) is a neurotransmitter that synthesized from L-arginine with faciltation of nitric oxide synthase (NOS). Nitric oxide is essential and required in central nervous system (CNS) and peripheral nervous system (PNS). Nitric oxide has several important functions such as immune responses, blood flow regulation and modulation of neurotransmission. Nitric oxide also participates in controlling sleep, adjusting body temperature, neurosecretion as well as synaptic modulation and plasticity in CNS. While in PNS, nitric oxide participates in visceral smooth muscle relaxation as well as vasodilation mediation.
References
Nitric Oxide Signaling Pathway References
Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S: Molecular cloning and characterization of the rat NMDA receptor. Nature. 1991 Nov 7;354(6348):31-7. doi: 10.1038/354031a0.
Pubmed: 1834949
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Pubmed: 1386026
Nakanishi N, Axel R, Shneider NA: Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8552-6. doi: 10.1073/pnas.89.18.8552.
Pubmed: 1388270
Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH: Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 1992 May 22;256(5060):1217-21. doi: 10.1126/science.256.5060.1217.
Pubmed: 1350383
Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M, et al.: Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem. 1993 Feb 5;268(4):2836-43.
Pubmed: 8428958
Kornau HC, Schenker LT, Kennedy MB, Seeburg PH: Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995 Sep 22;269(5231):1737-40. doi: 10.1126/science.7569905.
Pubmed: 7569905
Cho KO, Hunt CA, Kennedy MB: The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron. 1992 Nov;9(5):929-42. doi: 10.1016/0896-6273(92)90245-9.
Pubmed: 1419001
Kistner U, Wenzel BM, Veh RW, Cases-Langhoff C, Garner AM, Appeltauer U, Voss B, Gundelfinger ED, Garner CC: SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem. 1993 Mar 5;268(7):4580-3.
Pubmed: 7680343
Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH: Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991 Jun 27;351(6329):714-8. doi: 10.1038/351714a0.
Pubmed: 1712077
Magee T, Fuentes AM, Garban H, Rajavashisth T, Marquez D, Rodriguez JA, Rajfer J, Gonzalez-Cadavid NF: Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract. Biochem Biophys Res Commun. 1996 Sep 4;226(1):145-51. doi: 10.1006/bbrc.1996.1324.
Pubmed: 8806605
Seo HG, Tatsumi H, Fujii J, Nishikawa A, Suzuki K, Kangawa K, Taniguchi N: Nitric oxide synthase from rat colorectum: purification, peptide sequencing, partial PCR cloning, and immunohistochemistry. J Biochem. 1994 Mar;115(3):602-7. doi: 10.1093/oxfordjournals.jbchem.a124382.
Pubmed: 7520037
Sherbany AA, Parent AS, Brosius J: Rat calmodulin cDNA. DNA. 1987 Jun;6(3):267-72. doi: 10.1089/dna.1987.6.267.
Pubmed: 2885164
Nojima H: Structural organization of multiple rat calmodulin genes. J Mol Biol. 1989 Jul 20;208(2):269-82. doi: 10.1016/0022-2836(89)90388-4.
Pubmed: 2527998
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Pubmed: 15489334
Ito A, Hashimoto T, Hirai M, Takeda T, Shuntoh H, Kuno T, Tanaka C: The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A. Biochem Biophys Res Commun. 1989 Sep 29;163(3):1492-7. doi: 10.1016/0006-291x(89)91148-0.
Pubmed: 2551293
Perrino BA, Fong YL, Brickey DA, Saitoh Y, Ushio Y, Fukunaga K, Miyamoto E, Soderling TR: Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform. J Biol Chem. 1992 Aug 5;267(22):15965-9.
Pubmed: 1322410
Chang CD, Takeda T, Mukai H, Shuntoh H, Kuno T, Tanaka C: Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene. Biochem J. 1992 Dec 15;288 ( Pt 3):801-5. doi: 10.1042/bj2880801.
Pubmed: 1335233
Ono Y, Fujii T, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y: Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C. Nucleic Acids Res. 1988 Jun 10;16(11):5199-200. doi: 10.1093/nar/16.11.5199.
Pubmed: 3387228
Kikkawa U, Ogita K, Ono Y, Asaoka Y, Shearman MS, Fujii T, Ase K, Sekiguchi K, Igarashi K, Nishizuka Y: The common structure and activities of four subspecies of rat brain protein kinase C family. FEBS Lett. 1987 Nov 2;223(2):212-6. doi: 10.1016/0014-5793(87)80291-0.
Pubmed: 3666147
Mineo C, Ying YS, Chapline C, Jaken S, Anderson RG: Targeting of protein kinase Calpha to caveolae. J Cell Biol. 1998 May 4;141(3):601-10. doi: 10.1083/jcb.141.3.601.
Pubmed: 9566962
Shuntoh H, Sakamoto N, Matsuyama S, Saitoh M, Tanaka C: Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells. Biochim Biophys Acta. 1992 Jun 15;1131(2):175-80. doi: 10.1016/0167-4781(92)90073-9.
Pubmed: 1610898
Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
Pubmed: 9521123
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063777
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