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Pathway Description
Phospholipase C Signaling Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Kinase Signaling
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-13
Phospholipase C pathways is one of the major intracellular signalling pathways regulating hormones. It functions to activate inositol lipid signalling pathways causing the hydrolysis of PIP2 by PLC to IP3 and diacylglycerol to activate protein kinase C. IP3 releases calcium from the endoplasmic reticulum. PIP3 is an important regulator of AKT signaling and downstream pathways.
References
Phospholipase C Signaling Pathway References
Suh PG, Ryu SH, Moon KH, Suh HW, Rhee SG: Cloning and sequence of multiple forms of phospholipase C. Cell. 1988 Jul 15;54(2):161-9. doi: 10.1016/0092-8674(88)90548-x.
Pubmed: 3390863
Jhon DY, Lee HH, Park D, Lee CW, Lee KH, Yoo OJ, Rhee SG: Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3. J Biol Chem. 1993 Mar 25;268(9):6654-61.
Pubmed: 8454637
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Suh PG, Ryu SH, Moon KH, Suh HW, Rhee SG: Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5419-23. doi: 10.1073/pnas.85.15.5419.
Pubmed: 2840660
Lee SJ, Ryu SH, Suh PG: Promoter region of the rat phospholipase C-gamma 1 gene. Biochem Biophys Res Commun. 1993 Jul 15;194(1):294-300. doi: 10.1006/bbrc.1993.1818.
Pubmed: 8392838
Vainikka S, Joukov V, Wennstrom S, Bergman M, Pelicci PG, Alitalo K: Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1. J Biol Chem. 1994 Jul 15;269(28):18320-6.
Pubmed: 7518429
Tannert A, Voigt P, Burgold S, Tannert S, Schaefer M: Signal amplification between Gbetagamma release and PI3Kgamma-mediated PI(3,4,5)P3 formation monitored by a fluorescent Gbetagamma biosensor protein and repetitive two component total internal reflection/fluorescence redistribution after photobleaching analysis. Biochemistry. 2008 Oct 28;47(43):11239-50. doi: 10.1021/bi800596b. Epub 2008 Oct 2.
Pubmed: 18831540
Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ: Akt1 and Akt2: differentiating the aktion. Histol Histopathol. 2011 May;26(5):651-62. doi: 10.14670/HH-26.651.
Pubmed: 21432781
Konishi H, Shinomura T, Kuroda S, Ono Y, Kikkawa U: Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Biochem Biophys Res Commun. 1994 Nov 30;205(1):817-25. doi: 10.1006/bbrc.1994.2738.
Pubmed: 7999118
Kitamura T, Ogawa W, Sakaue H, Hino Y, Kuroda S, Takata M, Matsumoto M, Maeda T, Konishi H, Kikkawa U, Kasuga M: Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol. 1998 Jul;18(7):3708-17. doi: 10.1128/mcb.18.7.3708.
Pubmed: 9632753
Song JS, Haleem-Smith H, Arudchandran R, Gomez J, Scott PM, Mill JF, Tan TH, Rivera J: Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway. J Immunol. 1999 Jul 15;163(2):802-10.
Pubmed: 10395673
Ono Y, Fujii T, Igarashi K, Kikkawa U, Ogita K, Nishizuka Y: Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat brain protein kinase C. Nucleic Acids Res. 1988 Jun 10;16(11):5199-200. doi: 10.1093/nar/16.11.5199.
Pubmed: 3387228
Kikkawa U, Ogita K, Ono Y, Asaoka Y, Shearman MS, Fujii T, Ase K, Sekiguchi K, Igarashi K, Nishizuka Y: The common structure and activities of four subspecies of rat brain protein kinase C family. FEBS Lett. 1987 Nov 2;223(2):212-6. doi: 10.1016/0014-5793(87)80291-0.
Pubmed: 3666147
Mineo C, Ying YS, Chapline C, Jaken S, Anderson RG: Targeting of protein kinase Calpha to caveolae. J Cell Biol. 1998 May 4;141(3):601-10. doi: 10.1083/jcb.141.3.601.
Pubmed: 9566962
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063783
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