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Pathway Description
Pancreas Function
Bos taurus
Category:
Metabolite Pathway
Sub-Category:
Physiological
Created: 2018-09-10
Last Updated: 2019-09-13
The pancreas is crucial in many organisms for properly converting food into usable fuel to be used by cells. It acts as part of the digestive system for a majority of its function as it is connected to the stomach and provides digestive enzymes to the partly digested food brought in by the stomach. The pancreas also serves as an endocrine component, by creating hormones to regulate blood sugar. Insulin, a hormone created by the pancreas, acts to lower blood sugar, which is very important as it allows cells in the body to use sugar without inducing hyperglycaemia.
References
Pancreas Function References
Augustin R, Pocar P, Navarrete-Santos A, Wrenzycki C, Gandolfi F, Niemann H, Fischer B: Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos. Mol Reprod Dev. 2001 Nov;60(3):370-6. doi: 10.1002/mrd.1099.
Pubmed: 11599048
Taguchi Y, Saeki K, Komano T: Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
Pubmed: 12067707
Andres-Mateos E, Cruces J, Renart J, Solis-Garrido LM, Serantes R, de Lucas-Cerrillo AM, Montiel C: Bovine CACNA1A gene and comparative analysis of the CAG repeats associated to human spinocerebellar ataxia type-6. Gene. 2006 Sep 15;380(1):54-61. doi: 10.1016/j.gene.2006.06.003. Epub 2006 Jun 22.
Pubmed: 16876337
Andres-Mateos E, Renart J, Cruces J, Solis-Garrido LM, Serantes R, de Lucas-Cerrillo AM, Aldea M, Garcia AG, Montiel C: Dynamic association of the Ca2+ channel alpha1A subunit and SNAP-25 in round or neurite-emitting chromaffin cells. Eur J Neurosci. 2005 Nov;22(9):2187-98. doi: 10.1111/j.1460-9568.2005.04385.x.
Pubmed: 16262657
Cahill AL, Hurley JH, Fox AP: Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells. J Neurosci. 2000 Mar 1;20(5):1685-93.
Pubmed: 10684870
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
D'Agostino J, Younes MA, White JW, Besch PK, Field JB, Frazier ML: Cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for bovine preproinsulin. Mol Endocrinol. 1987 Apr;1(4):327-31. doi: 10.1210/mend-1-4-327.
Pubmed: 2456452
Nolan C, Margoliash E, Peterson JD, Steiner DF: The structure of bovine proinsulin. J Biol Chem. 1971 May 10;246(9):2780-95.
Pubmed: 4928892
SANGER F, TUPPY H: The amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates. Biochem J. 1951 Sep;49(4):481-90. doi: 10.1042/bj0490481.
Pubmed: 14886311
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000643
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