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Pathway Description
Pancreas Function
Rattus norvegicus
Category:
Metabolite Pathway
Sub-Category:
Physiological
Created: 2018-09-10
Last Updated: 2019-09-13
The pancreas is crucial in many organisms for properly converting food into usable fuel to be used by cells. It acts as part of the digestive system for a majority of its function as it is connected to the stomach and provides digestive enzymes to the partly digested food brought in by the stomach. The pancreas also serves as an endocrine component, by creating hormones to regulate blood sugar. Insulin, a hormone created by the pancreas, acts to lower blood sugar, which is very important as it allows cells in the body to use sugar without inducing hyperglycaemia.
References
Pancreas Function References
Thorens B, Sarkar HK, Kaback HR, Lodish HF: Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell. 1988 Oct 21;55(2):281-90. doi: 10.1016/0092-8674(88)90051-7.
Pubmed: 3048704
Ahn YH, Kim JW, Han GS, Lee BG, Kim YS: Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization. Arch Biochem Biophys. 1995 Nov 10;323(2):387-96. doi: 10.1006/abbi.1995.0059.
Pubmed: 7487103
Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP 4th, Boyd AE 3rd, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA: Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science. 1995 Apr 21;268(5209):423-6. doi: 10.1126/science.7716547.
Pubmed: 7716547
Nelson DA, Bryan J, Wechsler S, Clement JP 4th, Aguilar-Bryan L: The high-affinity sulfonylurea receptor: distribution, glycosylation, purification, and immunoprecipitation of two forms from endocrine and neuroendocrine cell lines. Biochemistry. 1996 Nov 26;35(47):14793-9. doi: 10.1021/bi960777y.
Pubmed: 8942641
Starr TV, Prystay W, Snutch TP: Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5621-5. doi: 10.1073/pnas.88.13.5621.
Pubmed: 1648226
Yu AS, Hebert SC, Brenner BM, Lytton J: Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10494-8. doi: 10.1073/pnas.89.21.10494.
Pubmed: 1279681
Snutch TP, Leonard JP, Gilbert MM, Lester HA, Davidson N: Rat brain expresses a heterogeneous family of calcium channels. Proc Natl Acad Sci U S A. 1990 May;87(9):3391-5. doi: 10.1073/pnas.87.9.3391.
Pubmed: 1692134
Pragnell M, Sakamoto J, Jay SD, Campbell KP: Cloning and tissue-specific expression of the brain calcium channel beta-subunit. FEBS Lett. 1991 Oct 21;291(2):253-8. doi: 10.1016/0014-5793(91)81296-k.
Pubmed: 1657644
Yang L, Katchman A, Morrow JP, Doshi D, Marx SO: Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits. FASEB J. 2011 Mar;25(3):928-36. doi: 10.1096/fj.10-172353. Epub 2010 Dec 2.
Pubmed: 21127204
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Chu PJ, Best PM: Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1. J Mol Cell Cardiol. 2003 Feb;35(2):207-15.
Pubmed: 12606261
Hatano S, Yamashita T, Sekiguchi A, Iwasaki Y, Nakazawa K, Sagara K, Iinuma H, Aizawa T, Fu LT: Molecular and electrophysiological differences in the L-type Ca2+ channel of the atrium and ventricle of rat hearts. Circ J. 2006 May;70(5):610-4. doi: 10.1253/circj.70.610.
Pubmed: 16636499
Lomedico P, Rosenthal N, Efstratidadis A, Gilbert W, Kolodner R, Tizard R: The structure and evolution of the two nonallelic rat preproinsulin genes. Cell. 1979 Oct;18(2):545-58. doi: 10.1016/0092-8674(79)90071-0.
Pubmed: 498284
Soares MB, Schon E, Henderson A, Karathanasis SK, Cate R, Zeitlin S, Chirgwin J, Efstratiadis A: RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol Cell Biol. 1985 Aug;5(8):2090-103. doi: 10.1128/mcb.5.8.2090.
Pubmed: 2427930
Lomedico PT, Rosenthal N, Kolodner R, Efstratiadis A, Gilbert W: The structure of rat preproinsulin genes. Ann N Y Acad Sci. 1980;343:425-32. doi: 10.1111/j.1749-6632.1980.tb47271.x.
Pubmed: 6249167
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000643
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