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Bis(5'-
nucleosyl)-
tetraphosphatase
[asymmetrical]
Nucleoside
diphosphate
kinase 6
Ectonucleoside
triphosphate
diphosphohydrolase
5
Ectonucleoside
triphosphate
diphosphohydrolase
8
Guanylate
kinase
Nucleoside
diphosphate
kinase 6
Guanylate
kinase
Cytosolic
purine
5'-nucleotidase
Deoxyguanosine
kinase
Adenine
phosphoribosyltransferase
Cytosolic
purine
5'-nucleotidase
Purine
nucleoside
phosphorylase
Hypoxanthine-
guanine
phosphoribosyltransferase
Purine
nucleoside
phosphorylase
Guanine
deaminase
ADP-sugar
pyrophosphatase
Ribose-
phosphate
pyrophosphokinase
1
Amidophosphoribosyltransferase
Trifunctional
purine
biosynthetic
protein
adenosine-3
Trifunctional
purine
biosynthetic
protein
adenosine-3
Phosphoribosylformylglycinamidine
synthase
Multifunctional
protein ADE2
Multifunctional
protein ADE2
Adenylosuccinate
lyase
Bifunctional
purine
biosynthesis
protein PURH
Bifunctional
purine
biosynthesis
protein PURH
Inosine
triphosphate
pyrophosphatase
GMP synthase
[glutamine-
hydrolyzing]
Inosine-5'-
monophosphate
dehydrogenase 1
GMP reductase 1
Cytosolic
purine
5'-nucleotidase
Purine
nucleoside
phosphorylase
Cytosolic
purine
5'-nucleotidase
Hypoxanthine-
guanine
phosphoribosyltransferase
Purine
nucleoside
phosphorylase
Hypoxanthine-
guanine
phosphoribosyltransferase
Xanthine
dehydrogenase/oxidase
Xanthine
dehydrogenase/oxidase
Purine
nucleoside
phosphorylase
Adenylosuccinate
synthetase
isozyme 2
AMP deaminase 1
Adenylosuccinate
lyase
Adenosine
deaminase
Purine
nucleoside
phosphorylase
Purine
nucleoside
phosphorylase
Adenosine
deaminase
Adenine
phosphoribosyltransferase
Ectonucleoside
triphosphate
diphosphohydrolase
5
Adenylate
kinase
isoenzyme 1
ATPase family
AAA domain-
containing
protein 1
cAMP-specific
3',5'-cyclic
phosphodiesterase
4D
Adenylate
kinase
isoenzyme 1
Cytosolic
purine
5'-nucleotidase
Nucleoside
diphosphate
kinase 6
Guanylate
cyclase
cAMP and
cAMP-inhibited
cGMP
3',5'-cyclic
phosphodiesterase
10A
Ectonucleoside
triphosphate
diphosphohydrolase
8
Inosine
triphosphate
pyrophosphatase
Nucleoside
diphosphate
kinase 6
Ectonucleoside
triphosphate
diphosphohydrolase
8
Adenine
phosphoribosyltransferase
Trifunctional
purine
biosynthetic
protein
adenosine-3
Thioredoxin
Thioredoxin
Ribonucleoside-
diphosphate
reductase large
subunit
Ribonucleoside-
diphosphate
reductase
subunit M2
Ectonucleoside
triphosphate
diphosphohydrolase
5
Thioredoxin
Thioredoxin
Ribonucleoside-
diphosphate
reductase large
subunit
Ribonucleoside-
diphosphate
reductase
subunit M2
Phosphoribosyl pyrophosphate
Diguanosine tetraphosphate
H
2
O
Guanosine triphosphate
Guanosine monophosphate
Accumulation
ATP
Guanosine diphosphate
Accumulation
ADP
H
2
O
Guanosine monophosphate
P
i
H
2
O
P
i
Accumulation
ATP
Accumulation
ADP
Accumulation
ATP
dGDP
Accumulation
ADP
dGTP
Accumulation
ATP
2'-Deoxyguanosine
5'-monophosphate
Accumulation
ADP
H
2
O
Deoxyguanosine
P
i
Accumulation
ATP
Accumulation
ADP
PP
i
Guanine
Phosphoribosyl pyrophosphate
H
2
O
Guanosine
P
i
P
i
Ribose
1-phosphate
PP
i
Phosphoribosyl pyrophosphate
P
i
Deoxyribose
1-phosphate
H
2
O
Xanthine
NH
3
Adenosine diphosphate ribose
H
2
O
AMP
D-Ribose 5-phosphate
Accumulation
ATP
AMP
5-Phosphoribosylamine
PP
i
L-Glutamic acid
L-Glutamine
H
2
O
Accumulation
ATP
Glycine
Accumulation
ADP
P
i
Glycineamideribotide
10-Formyltetrahydrofolate
Tetrahydrofolic acid
5'-Phosphoribosyl-N-
formylglycinamide
Accumulation
ATP
H
2
O
Accumulation
ADP
P
i
Phosphoribosylformylglycineamidine
5-amino-1-(5-phospho-D-
ribosyl)imidazole-4-
carboxylate
5-Aminoimidazole
ribonucleotide
CO
2
Accumulation
ATP
L-Aspartic acid
Accumulation
ADP
P
i
SAICAR
Fumaric acid
AICAR
10-Formyltetrahydrofolate
Tetrahydrofolic acid
Phosphoribosyl
formamidocarboxamide
Inosinic acid
H
2
O
H
2
O
PP
i
Accumulation
ATP
Xanthylic acid
NH
3
AMP
PP
i
NAD
H
2
O
NADH
NH
3
NADP
NADPH
H
2
O
Xanthosine
P
i
P
i
Ribose
1-phosphate
H
2
O
Inosine
P
i
PP
i
Phosphoribosyl pyrophosphate
P
i
Hypoxanthine
Ribose
1-phosphate
PP
i
O
2
H
2
O
H
2
O
2
NAD
H
2
O
Uric acid
NADH
Deoxyinosine
P
i
Deoxyribose
1-phosphate
GTP
L-Aspartic acid
GDP
P
i
Adenylsuccinic acid
Adenosine monophosphate
H
2
O
NH
3
Fumaric acid
Accumulation
Adenosine
H
2
O
NH
3
P
i
Accumulation
Adenine
Ribose
1-phosphate
Deoxyadenosine
P
i
Deoxyribose
1-phosphate
H
2
O
NH
3
PP
i
Phosphoribosyl pyrophosphate
Accumulation
Adenosine diphosphate
H
2
O
P
i
Accumulation
Adenosine triphosphate
H
2
O
P
i
cAMP
H
2
O
PP
i
Accumulation
ATP
Deoxyadenosine monophosphate
Accumulation
ADP
dADP
H
2
O
P
i
Accumulation
ATP
Accumulation
ADP
Accumulation
Deoxyadenosine triphosphate
Guanosine 2',3'-cyclic
phosphate
PP
i
H
2
O
IDP
H
2
O
P
i
Inosine triphosphate
H
2
O
PP
i
Accumulation
ATP
Accumulation
ADP
H
2
O
P
i
PP
i
5-Aminoimidazole-4-carboxamide
Phosphoribosyl pyrophosphate
Accumulation
ATP
Accumulation
ADP
P
i
H
2
O
P
i
H
2
O
H
2
O
Magnesium
Calcium
Magnesium
Calcium
Magnesium
Magnesium
Magnesium
Magnesium
Zinc (II) ion
Magnesium
Magnesium
Magnesium
Potassium
Magnesium
Magnesium
Magnesium
Magnesium
FAD
FAD
Magnesium
Zinc (II) ion
Zinc (II) ion
Zinc (II) ion
Calcium
Magnesium
Zinc (II) ion
Magnesium
Magnesium
Heme
Zinc (II) ion
Magnesium
Calcium
Magnesium
Magnesium
Calcium
Disulfide
Fe3+
Calcium
Magnesium
Disulfide
Fe3+
Pentose
Phosphate
Pathway
Endoplasmic Reticulum
Peroxisome
Endoplasmic Reticulum
Peroxisome
Intracellular Space
Extracellular Space
Mitochondria
Nudt2
Nme6
Entpd5
Entpd8
Guk1
Nme6
Guk1
Nt5c2
Dguok
Aprt
Nt5c2
Pnp
Hprt1
Pnp
Gda
Nudt5
Prps1
Ppat
Gart
Gart
Pfas
Paics
Paics
Adsl
Atic
Atic
Itpa
Gmps
Impdh1
Gmpr
Nt5c2
Pnp
Nt5c2
Hprt1
Pnp
Hprt1
Xdh
Xdh
Pnp
Adss
Ampd1
Adsl
Ada
Pnp
Pnp
Ada
Aprt
Entpd5
Ak1
Atad1
Pde4d
Ak1
Nt5c2
Nme6
Gucy1a1
Gucy1b1
Pde10a
Entpd8
Itpa
Nme6
Entpd8
Aprt
Gart
Txn
Txn
Rrm1
Rrm2
Entpd5
Txn
Txn
Rrm1
Rrm2
Phosphoribosyl
pyrophosphate
Diguanosine
tetraphosphate
Water
Guanosine
triphosphate
Guanosine
monophosphate
Accumulation
Adenosine
triphosphate
Guanosine
diphosphate
Accumulation
Adenosine
diphosphate
Water
Guanosine
monophosphate
Phosphate
Water
Phosphate
Accumulation
Adenosine
triphosphate
Accumulation
Adenosine
diphosphate
Accumulation
Adenosine
triphosphate
dGDP
Accumulation
Adenosine
diphosphate
dGTP
Accumulation
Adenosine
triphosphate
2'-
Deoxyguanosine
5'-
monophosphate
Accumulation
Adenosine
diphosphate
Water
Deoxyguanosine
Phosphate
Accumulation
Adenosine
triphosphate
Accumulation
Adenosine
diphosphate
Pyrophosphate
Guanine
Phosphoribosyl
pyrophosphate
Water
Guanosine
Phosphoric acid
Phosphate
Ribose
1-phosphate
Pyrophosphate
Phosphoribosyl
pyrophosphate
Phosphate
Deoxyribose
1-phosphate
Water
Xanthine
Ammonia
Adenosine
diphosphate
ribose
Water
Adenosine
monophosphate
D-Ribose
5-phosphate
Accumulation
Adenosine
triphosphate
Adenosine
monophosphate
5-
Phosphoribosylamine
Pyrophosphate
L-Glutamic acid
L-Glutamine
Water
Accumulation
Adenosine
triphosphate
Glycine
Accumulation
Adenosine
diphosphate
Phosphate
Glycineamideribotide
10-
Formyltetrahydrofolate
Tetrahydrofolic
acid
5'-
Phosphoribosyl-
N-
formylglycinamide
Accumulation
Adenosine
triphosphate
Water
Accumulation
Adenosine
diphosphate
Phosphoric acid
Phosphoribosylformylglycineamidine
5-amino-1-(5-
phospho-D-
ribosyl)imidazole-
4-carboxylate
5-
Aminoimidazole
ribonucleotide
Carbon dioxide
Accumulation
Adenosine
triphosphate
L-Aspartic acid
Accumulation
Adenosine
diphosphate
Phosphoric acid
SAICAR
Fumaric acid
AICAR
10-
Formyltetrahydrofolate
Tetrahydrofolic
acid
Phosphoribosyl
formamidocarboxamide
Inosinic acid
Water
Water
Pyrophosphate
Accumulation
Adenosine
triphosphate
Xanthylic acid
Ammonia
Adenosine
monophosphate
Pyrophosphate
NAD
Water
NADH
Ammonia
NADP
NADPH
Water
Xanthosine
Phosphate
Phosphate
Ribose
1-phosphate
Water
Inosine
Phosphate
Pyrophosphate
Phosphoribosyl
pyrophosphate
Phosphate
Hypoxanthine
Ribose
1-phosphate
Pyrophosphate
Oxygen
Water
Hydrogen
peroxide
NAD
Water
Uric acid
NADH
Deoxyinosine
Phosphate
Deoxyribose
1-phosphate
Guanosine
triphosphate
L-Aspartic acid
Guanosine
diphosphate
Phosphate
Adenylsuccinic
acid
Adenosine
monophosphate
Water
Ammonia
Fumaric acid
Accumulation
Adenosine
Water
Ammonia
Phosphate
Accumulation
Adenine
Ribose
1-phosphate
Deoxyadenosine
Phosphate
Deoxyribose
1-phosphate
Water
Ammonia
Pyrophosphate
Phosphoribosyl
pyrophosphate
Accumulation
Adenosine
diphosphate
Water
Phosphoric acid
Accumulation
Adenosine
triphosphate
Water
Phosphoric acid
cAMP
Water
Pyrophosphate
Accumulation
Adenosine
triphosphate
Deoxyadenosine
monophosphate
Accumulation
Adenosine
diphosphate
dADP
Water
Phosphoric acid
Accumulation
Adenosine
triphosphate
Accumulation
Adenosine
diphosphate
Accumulation
Deoxyadenosine
triphosphate
Guanosine
2',3'-cyclic
phosphate
Pyrophosphate
Water
IDP
Water
Phosphate
Inosine
triphosphate
Water
Pyrophosphate
Accumulation
Adenosine
triphosphate
Accumulation
Adenosine
diphosphate
Water
Phosphate
Pyrophosphate
5-
Aminoimidazole-
4-carboxamide
Phosphoribosyl
pyrophosphate
Accumulation
Adenosine
triphosphate
Accumulation
Adenosine
diphosphate
Phosphate
Water
Phosphate
Water
Water
Pentose
Phosphate
Pathway
Nudt2
Nme6
Entpd5
Entpd8
Guk1
Nme6
Guk1
Nt5c2
Dguok
Aprt
Nt5c2
Pnp
Hprt1
Pnp
Gda
Nudt5
Prps1
Ppat
Gart
Gart
Pfas
Paics
Paics
Adsl
Atic
Atic
Itpa
Gmps
Impdh1
Gmpr
Nt5c2
Pnp
Nt5c2
Hprt1
Pnp
Hprt1
Xdh
Xdh
Pnp
Adss
Ampd1
Adsl
Ada
Pnp
Pnp
Ada
Aprt
Entpd5
Ak1
Atad1
Pde4d
Ak1
Nt5c2
Nme6
Gucy1a1
Gucy1b1
Pde10a
Entpd8
Itpa
Nme6
Entpd8
Aprt
Gart
Txn
Txn
Rrm1
Rrm2
Entpd5
Txn
Txn
Rrm1
Rrm2
PRPP
Guan2P4
H
2
O
GTP
GSMP
Accumulation
ATP
GDP
Accumulation
ADP
H
2
O
GSMP
P
i
H
2
O
P
i
Accumulation
ATP
Accumulation
ADP
Accumulation
ATP
dGDP
Accumulation
ADP
dGTP
Accumulation
ATP
dGMP
Accumulation
ADP
H
2
O
doxyG
P
i
Accumulation
ATP
Accumulation
ADP
PP
i
Guanine
PRPP
H
2
O
Guo
P
i
P
i
Rib-1P
PP
i
PRPP
P
i
D1P
H
2
O
Xanthin
NH
3
ADP-Rib
H
2
O
AMP
DRib-5P
Accumulation
ATP
AMP
5-PPRSA
PP
i
Glu
Gln
H
2
O
Accumulation
ATP
Gly
Accumulation
ADP
P
i
Glyadbt
10-FTHF
THFA
5PPNFG
Accumulation
ATP
H
2
O
Accumulation
ADP
P
i
FGAM
CR
5-AnRbn
CO
2
Accumulation
ATP
Asp
Accumulation
ADP
P
i
SAICAR
Fumarat
AICAR
10-FTHF
THFA
FosbFca
Imp
H
2
O
H
2
O
PP
i
Accumulation
ATP
XntylcA
NH
3
AMP
PP
i
NAD
H
2
O
NADH
NH
3
NADP
NADPH
H
2
O
Xanthos
P
i
P
i
Rib-1P
H
2
O
Inosine
P
i
PP
i
PRPP
P
i
Hyp
Rib-1P
PP
i
O
2
H
2
O
H
2
O
2
NAD
H
2
O
Urate
NADH
D-Ino
P
i
D1P
GTP
Asp
GDP
P
i
Asuca
AMP
H
2
O
NH
3
Fumarat
Accumulation
Adenosi
H
2
O
NH
3
P
i
Accumulation
Adenine
Rib-1P
DA
P
i
D1P
H
2
O
NH
3
PP
i
PRPP
Accumulation
ADP
H
2
O
P
i
Accumulation
ATP
H
2
O
P
i
cAMP
H
2
O
PP
i
Accumulation
ATP
dAMP
Accumulation
ADP
dADP
H
2
O
P
i
Accumulation
ATP
Accumulation
ADP
Accumulation
doATP
23CGMP
PP
i
H
2
O
IDP
H
2
O
P
i
Ino3P
H
2
O
PP
i
Accumulation
ATP
Accumulation
ADP
H
2
O
P
i
PP
i
5Ai4Ca
PRPP
Accumulation
ATP
Accumulation
ADP
P
i
H
2
O
P
i
H
2
O
H
2
O
Mg2+
Ca2+
Mg2+
Ca2+
Mg2+
Mg2+
Mg2+
Mg2+
Zinc
Mg2+
Mg2+
Mg2+
K+
Mg2+
Mg2+
Mg2+
Mg2+
FAD
FAD
Mg2+
Zinc
Zinc
Zinc
Ca2+
Mg2+
Zinc
Mg2+
Mg2+
Heme
Zinc
Mg2+
Ca2+
Mg2+
Mg2+
Ca2+
Disulfi
Fe3+
Ca2+
Mg2+
Disulfi
Fe3+
PW000055
Endoplasmic Reticulum
Peroxisome
Endoplasmic Reticulum
Peroxisome
Intracellular Space
Extracellular Space
Mitochondria