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Sialin
Chitotriosidase-
1
Beta-
hexosaminidase
subunit alpha
Chitotriosidase-
1
N-acetyl-D-
glucosamine
kinase
N-
acetylglucosamine-
6-phosphate
deacetylase
Glucosamine
6-phosphate N-
acetyltransferase
Glucosamine-
6-phosphate
isomerase 1
Glutamine--
fructose-6-
phosphate
aminotransferase
Phosphoacetylglucosamine
mutase
UDP-N-
acetylhexosamine
pyrophosphorylase
N-
acylglucosamine
2-epimerase
Bifunctional
UDP-N-acetyl
glucosamine
2-epimerase /
N-
acetylmannosamine
kinase
Hexokinase-1
Hexokinase-1
Sialic acid
synthase
N-
acetylneuraminate
lyase
Bifunctional
UDP-N-acetyl
glucosamine
2-epimerase /
N-
acetylmannosamine
kinase
Sialic acid
synthase
N-
acylneuraminate-
9-phosphatase
N-
acylneuraminate
cytidylyltransferase
Accumulation
N-Acetylneuraminic acid
Accumulation
N-Acetylneuraminic acid
Chitin
Chitobiose
H
2
O
N-Acetyl-D-glucosamine
ATP
ADP
N-Acetyl-D-Glucosamine
6-Phosphate
H
2
O
Glucosamine 6-phosphate
Acetic acid
Acetyl-CoA
CoA
H
2
O
Fructose 6-phosphate
NH
3
L-Glutamine
L-Glutamic acid
N-Acetyl-glucosamine
1-phosphate
Uridine triphosphate
Uridine diphosphate-N-
acetylglucosamine
PP
i
N-Acetylmannosamine
H
2
O
Uridine 5'-diphosphate
D-Fructose
ATP
ADP
Glucosamine
ATP
ADP
Phosphoenolpyruvic acid
H
2
O
P
i
Pyruvic acid
ATP
N-Acetyl-D-mannosamine
6-phosphate
ADP
Phosphoenolpyruvic acid
H
2
O
N-Acetylneuraminate
9-phosphate
P
i
H
2
O
P
i
Cytidine triphosphate
Cytidine monophosphate N-acetylneuraminic
acid
PP
i
Magnesium
Magnesium
Extracellular Space
Intracellular Space
Lysosome
Lysosome