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GTP
cyclohydrolase
GTP
cyclohydrolase
GTP
cyclohydrolase
GTP
cyclohydrolase
6-pyruvoyl
tetrahydrobiopterin
synthase
Sepiapterin
reductase
Sepiapterin
reductase
Aldose
reductase
Carbonyl
reductase
[NADPH] 1
Sepiapterin
reductase
Carbonyl
reductase
[NADPH] 1
Sepiapterin
reductase
Dihydrofolate
reductase
Dihydropteridine
reductase
Sepiapterin
reductase
Guanosine triphosphate
Formamidopyrimidine nucleoside
triphosphate
H
2
O
2,5-Diaminopyrimidine
nucleoside triphosphate
Formic acid
H
2
O
Formic acid
2,5-Diamino-6-(5'-
triphosphoryl-3',4'-
trihydroxy-2'-oxopentyl)-
amino-4-oxopyrimidine
Dihydroneopterin triphosphate
H
2
O
Dyspropterin
PPPi
NADP
NADPH
1-hydroxy-2-Oxopropyl
tetrahydropterin
NADP
6-Lactoyltetrahydropterin
NADPH
NADP
NADPH
Sepiapterin
NADPH
7,8-Dihydroneopterin
NADP
NADP
NADPH
NADP
Tetrahydrobiopterin
NADPH
NADPH
NADP
H
2
O
Accumulation
Neopterin
NADP
Dihydrobiopterin
NADPH
NAD
NADH
Zinc
Zinc
Zinc
Zinc
Zinc
Purine
Metabolism
Intracellular space
Gch1
Gch1
Gch1
Gch1
Pts
Spr
Spr
Akr1b1
Cbr1
Spr
Cbr1
Spr
Dhfr
Qdpr
Spr
Guanosine
triphosphate
Formamidopyrimidine
nucleoside
triphosphate
Water
2,5-
Diaminopyrimidine
nucleoside
triphosphate
Formic acid
Water
Formic acid
2,5-Diamino-
6-(5'-
triphosphoryl-
3',4'-
trihydroxy- 2'-
oxopentyl)-
amino-4-
oxopyrimidine
Dihydroneopterin
triphosphate
Water
Dyspropterin
PPPi
NADP
NADPH
1-hydroxy-2-
Oxopropyl
tetrahydropterin
NADP
6-
Lactoyltetrahydropterin
NADPH
NADP
NADPH
Sepiapterin
NADPH
7,8-
Dihydroneopterin
NADP
NADP
NADPH
NADP
Tetrahydrobiopterin
NADPH
NADPH
NADP
Water
Accumulation
Neopterin
NADP
Dihydrobiopterin
NADPH
NAD
NADH
Purine
Metabolism