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Tyrosine aminotransferase Aspartate aminotransferase, cytoplasmic 4- hydroxyphenylpyruvate dioxygenase Maleylacetoacetate isomerase Fumarylacetoacetase Aromatic-L- amino-acid decarboxylase Aldehyde dehydrogenase, dimeric NADP-preferring Tyrosinase Dopamine beta- hydroxylase Aromatic-L- amino-acid decarboxylase Tyrosinase Tyrosinase Tyrosinase L-dopachrome tautomerase Tyrosinase Phenylethanolamine N- methyltransferase Amine oxidase [flavin- containing] A Amine oxidase [flavin- containing] A Amine oxidase [flavin- containing] A Amine oxidase [flavin- containing] A Aldehyde dehydrogenase, dimeric NADP-preferring Alcohol dehydrogenase 1 Amine oxidase [flavin- containing] A Amine oxidase [flavin- containing] A 3- hydroxyanthranilate 3,4-dioxygenase Aldehyde dehydrogenase, dimeric NADP-preferring Homogentisate 1,2-dioxygenase Macrophage migration inhibitory factor Amiloride- sensitive amine oxidase [copper- containing] Amine oxidase [flavin- containing] A Tyrosinase Catechol O- methyltransferase Aldehyde dehydrogenase, dimeric NADP-preferring Catechol O- methyltransferase Catechol O- methyltransferase Catechol O- methyltransferase Catechol O- methyltransferase Catechol O- methyltransferase Accumulation L-Tyrosine Oxoglutaric acid Accumulation 4- Hydroxyphenylpyruvic acid L-Glutamic acid L-Aspartic acid Oxalacetic acid O2 Homogentisic acid CO2 Maleylacetoacetic acid 4- Fumarylacetoacetic acid H2O Acetoacetic acid Fumaric acid Tyramine CO2 Homovanillin NADP H2O Accumulation p- Hydroxyphenylacetic acid NADPH O2 Dopamine H2O Ascorbic acid O2 Norepinephrine Dehydroascorbic acid H2O L-Dopa Tetrahydrobiopterin 4a- Hydroxytetrahydrobiopterin O2 Dopaquinone H2O Leucodopachrome L-Dopachrome O2 5,6- Dihydroxyindole H2O O2 Indole-5,6- quinone H2O Melanin 5,6- Dihydroxyindole- 2-carboxylic acid O2 H2O S- Adenosylmethionine S- Adenosylhomocysteine Epinephrine H2O O2 3,4- Dihydroxymandelaldehyde NH3 H2O2 H2O O2 Methylamine H2O2 Normetanephrine H2O O2 3-Methoxy-4- hydroxyphenylglycolaldehyde NH3 H2O2 Metanephrine H2O O2 NH3 H2O2 NAD H2O 3,4- Dihydroxymandelic acid NADH H+ NAD NADH 3,4- Dihydroxyphenylglycol Dopamine H2O O2 3,4- Dihydroxyphenylacetaldehyde NH3 H2O2 3- Methoxytyramine H2O O2 Homovanillin H2O2 NH3 NAD H2O 3,4- Dihydroxybenzeneacetic acid NADH H+ NAD H2O Homovanillic acid NADH H+ O2 2-Hydroxy-3- (4- hydroxyphenyl)propenoic acid H2O O2 H2O2 NH3 H2O O2 H2O2 NH3 O2 H2O Guaiacol Pyrocatechol NADP H2O Vanillylmandelic acid NADPH Guaiacol Pyrocatechol Guaiacol Vanylglycol Pyrocatechol Guaiacol Pyrocatechol Guaiacol Pyrocatechol Guaiacol Pyrocatechol Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Fe3+ Calcium Magnesium Pyridoxal 5'-phosphate Copper Pyrroloquinoline quinone Copper Pyridoxal 5'-phosphate Copper Copper Copper Zinc Copper FAD FAD FAD FAD Zinc FAD FAD Iron Copper Calcium Topaquinone FAD Copper Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Phenylalanine and Tyrosine Metabolism Thyroid Hormone Synthesis Intracellular space Extracellular space
Tat Got1 Hpd Gstz1 Fah Ddc Aldh3a1 Tyr Dbh Ddc Tyr Tyr Tyr Dct Tyr Pnmt Maoa Maoa Maoa Maoa Aldh3a1 Adh1 Maoa Maoa Haao Aldh3a1 Hgd Mif Aoc1 Maoa Tyr Comt Aldh3a1 Comt Comt Comt Comt Comt Accumulation L-Tyrosine Oxoglutaric acid Accumulation 4- Hydroxyphenylpyruvic acid L-Glutamic acid L-Aspartic acid Oxalacetic acid Oxygen Homogentisic acid Carbon dioxide Maleylacetoacetic acid 4- Fumarylacetoacetic acid Water Acetoacetic acid Fumaric acid Tyramine Carbon dioxide Homovanillin NADP Water Accumulation p- Hydroxyphenylacetic acid NADPH Oxygen Dopamine Water Ascorbic acid Oxygen Norepinephrine Dehydroascorbic acid Water L-Dopa Tetrahydrobiopterin 4a- Hydroxytetrahydrobiopterin Oxygen Dopaquinone Water Leucodopachrome L-Dopachrome Oxygen 5,6- Dihydroxyindole Water Oxygen Indole-5,6- quinone Water Melanin 5,6- Dihydroxyindole- 2-carboxylic acid Oxygen Water S- Adenosylmethionine S- Adenosylhomocysteine Epinephrine Water Oxygen 3,4- Dihydroxymandelaldehyde Ammonia Hydrogen peroxide Water Oxygen Methylamine Hydrogen peroxide Normetanephrine Water Oxygen 3-Methoxy-4- hydroxyphenylglycolaldehyde Ammonia Hydrogen peroxide Metanephrine Water Oxygen Ammonia Hydrogen peroxide NAD Water 3,4- Dihydroxymandelic acid NADH Hydrogen Ion NAD NADH 3,4- Dihydroxyphenylglycol Dopamine Water Oxygen 3,4- Dihydroxyphenylacetaldehyde Ammonia Hydrogen peroxide 3- Methoxytyramine Water Oxygen Homovanillin Hydrogen peroxide Ammonia NAD Water 3,4- Dihydroxybenzeneacetic acid NADH Hydrogen Ion NAD Water Homovanillic acid NADH Hydrogen Ion Oxygen 2-Hydroxy-3- (4- hydroxyphenyl)propenoic acid Water Oxygen Hydrogen peroxide Ammonia Water Oxygen Hydrogen peroxide Ammonia Oxygen Water Guaiacol Pyrocatechol NADP Water Vanillylmandelic acid NADPH Guaiacol Pyrocatechol Guaiacol Vanylglycol Pyrocatechol Guaiacol Pyrocatechol Guaiacol Pyrocatechol Guaiacol Pyrocatechol Phenylalanine and Tyrosine Metabolism Thyroid Hormone Synthesis
Tat Got1 Hpd Gstz1 Fah Ddc Aldh3a1 Tyr Dbh Ddc Tyr Tyr Tyr Dct Tyr Pnmt Maoa Maoa Maoa Maoa Aldh3a1 Adh1 Maoa Maoa Haao Aldh3a1 Hgd Mif Aoc1 Maoa Tyr Comt Aldh3a1 Comt Comt Comt Comt Comt Accumulation Tyr AKG Accumulation 4HPPA Glu Asp Oaa O2 HMGNCA CO2 MalaceA Fumaryl H2O LIN Fumarat Tyramin CO2 Homovan NADP H2O Accumulation p-Hpaa NADPH O2 LDP H2O VitC O2 Norpp DHAA H2O L-Dopa BH4 4aHtHbp O2 Dopqone H2O Leucpch L-Dopac O2 56-DHD H2O O2 ind56q H2O Melanin DHD-2CA O2 H2O SAMe SAH Eppy H2O O2 34DIHY NH3 H2O2 H2O O2 Methyla H2O2 Normeta H2O O2 4H3M NH3 H2O2 Meta-np H2O O2 NH3 H2O2 NAD H2O 34-DHMA NADH H+ NAD NADH DHPG LDP H2O O2 3,4-HPA NH3 H2O2 3-Motyr H2O O2 Homovan H2O2 NH3 NAD H2O 34DHBzA NADH H+ NAD H2O HVA NADH H+ O2 4AD H2O O2 H2O2 NH3 H2O O2 H2O2 NH3 O2 H2O Guajol Catecho NADP H2O VMA NADPH Guajol Catecho Guajol Vanygly Catecho Guajol Catecho Guajol Catecho Guajol Catecho Pyr-5'P Pyr-5'P Fe3+ Ca2+ Mg2+ Pyr-5'P Cu Pqq Cu Pyr-5'P Cu Cu Cu Zinc Cu FAD FAD FAD FAD Zinc FAD FAD Iron Cu Ca2+ TopQne FAD Cu Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ PW000042 PW000693 Intracellular space Extracellular space
Tat Got1 Hpd Gstz1 Fah Ddc Aldh3a1 Tyr Dbh Ddc Tyr Tyr Tyr Dct Tyr Pnmt Maoa Maoa Maoa Maoa Aldh3a1 Adh1 Maoa Maoa Haao Aldh3a1 Hgd Mif Aoc1 Maoa Tyr Comt Aldh3a1 Comt Comt Comt Comt Comt Accumulation Tyr AKG Accumulation 4HPPA Glu Asp Oaa O2 HMGNCA CO2 MalaceA Fumaryl H2O LIN Fumarat Tyramin CO2 Homovan NADP H2O Accumulation p-Hpaa NADPH O2 LDP H2O VitC O2 Norpp DHAA H2O L-Dopa BH4 4aHtHbp O2 Dopqone H2O Leucpch L-Dopac O2 56-DHD H2O O2 ind56q H2O Melanin DHD-2CA O2 H2O SAMe SAH Eppy H2O O2 34DIHY NH3 H2O2 H2O O2 Methyla H2O2 Normeta H2O O2 4H3M NH3 H2O2 Meta-np H2O O2 NH3 H2O2 NAD H2O 34-DHMA NADH H+ NAD NADH DHPG LDP H2O O2 3,4-HPA NH3 H2O2 3-Motyr H2O O2 Homovan H2O2 NH3 NAD H2O 34DHBzA NADH H+ NAD H2O HVA NADH H+ O2 4AD H2O O2 H2O2 NH3 H2O O2 H2O2 NH3 O2 H2O Guajol Catecho NADP H2O VMA NADPH Guajol Catecho Guajol Vanygly Catecho Guajol Catecho Guajol Catecho Guajol Catecho PW000042 PW000693