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Glutathione
synthetase
Glutathione
peroxidase 1
Glutathione
reductase,
mitochondrial
Glutathione
S-transferase
omega-2
Glutathione
hydrolase 6
Aminopeptidase
N
Caspase-7
Glutathione
hydrolase 6
Aminopeptidase
N
Caspase-7
Glutamate--
cysteine ligase
catalytic
subunit
Glutamate--
cysteine ligase
regulatory
subunit
5-oxoprolinase
Gamma-
glutamylcyclotransferase
Gamma-
glutamylcyclotransferase
L-Glutamic acid
Accumulation
L-Cysteine
ATP
Accumulation
γ-Glutamylcysteine
Glycine
ADP
P
i
Accumulation
Glutathione
H
2
O
2
Oxidized glutathione
H
2
O
NADPH
NADP
Bromomethane
Hydrogen
bromide
S-(methyl)glutathione
H
2
O
Methyl-S-Cysteinylglycine
H
2
O
Methyl-S-
cystein
Glycine
L-amino acid
(5-L-Glutamyl)-L-amino acid
Cysteinylglycine
H
2
O
ATP
L-Glutamic acid
ADP
P
i
ATP
Pyroglutamic acid
H
2
O
ADP
P
i
Accumulation
L-Cysteine
L-amino acid
FAD
Zinc (II) ion
Zinc
Zinc (II) ion
Zinc
Glutamate
Metabolism
Cysteine
Metabolism
Taurine and
Hypotaurine
Metabolism
Extracellular Space
Intracellular Space
Gamma Glutamyl cycle
Intracellular Space
Extracellular Space
Gss
Gpx1
Gsr
Gsto2
Ggt6
Anpep
Casp7
Ggt6
Anpep
Casp7
Gclc
Gclm
Oplah
Ggct
Ggct
L-Glutamic acid
Accumulation
L-Cysteine
Adenosine
triphosphate
Accumulation
γ-
Glutamylcysteine
Glycine
Adenosine
diphosphate
Phosphoric acid
Accumulation
Glutathione
Hydrogen
peroxide
Oxidized
glutathione
Water
NADPH
NADP
Bromomethane
Hydrogen
bromide
S-
(methyl)glutathione
Water
Methyl-S-
Cysteinylglycine
Water
Methyl-S-
cystein
Glycine
L-amino acid
(5-L-
Glutamyl)-L-
amino acid
Cysteinylglycine
Water
Adenosine
triphosphate
L-Glutamic acid
Adenosine
diphosphate
Phosphoric acid
Adenosine
triphosphate
Pyroglutamic
acid
Water
Adenosine
diphosphate
Phosphoric acid
Accumulation
L-Cysteine
L-amino acid
Glutamate
Metabolism
Cysteine
Metabolism
Taurine and
Hypotaurine
Metabolism