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Serine
palmitoyltransferase
2
Serine
palmitoyltransferase
1
3-
ketodihydrosphingosine
reductase
Sphingosine
kinase 2
Sphingosine-
1-phosphate
phosphatase 2
Phospholipid
phosphatase 1
Sphingosine-
1-phosphate
lyase 1
Sphingolipid
delta(4)-
desaturase/C4-
monooxygenase
DES2
Sphingosine-
1-phosphate
lyase 1
Sphingosine
kinase 2
Sphingosine-
1-phosphate
phosphatase 2
Phospholipid
phosphatase 1
Alkaline
ceramidase 1
Ceramide kinase
Phospholipid
phosphatase 1
Sphingosine-
1-phosphate
phosphatase 2
Phosphatidylcholine:ceramide
cholinephosphotransferase
1
Ectonucleotide
pyrophosphatase/phosphodiesterase
family member 5
2-
hydroxyacylsphingosine
1-beta-
galactosyltransferase
Galactocerebrosidase
Glucosylceramidase
Ceramide
glucosyltransferase
Unknown
Beta-1,4-
galactosyltransferase
6
Galactosylceramide
sulfotransferase
Arylsulfatase A
Alpha-
galactosidase A
Galactosylceramide
sulfotransferase
Sialidase-3
Alkaline
ceramidase 3
L-Serine
Palmityl-CoA
3-Dehydrosphinganine
Sphinganine
NADPH
NADP
ATP
ADP
Sphinganine 1-phosphate
ADP
ATP
P
i
O-
Phosphoethanolamine
Dihydroceramide
Ceramide (d18:1/18:0)
Sphingosine 1-phosphate
Sphingosine
ATP
ADP
ADP
ATP
P
i
ATP
CerP(d18:1/12:0)
ADP
P
i
SM(d18:1/18:0)
Galactosylceramide
(d18:1/16:0)
Glucosylceramide
Lactosylceramide (d18:1/12:0)
Phosphoadenosine
phosphosulfate
3-O-Sulfogalactosylceramide
(d18:1/24:0)
Adenosine
3',5'-
diphosphate
H
2
O
Sulfate
D-Galactose
Galabiosylceramide
(d18:1/22:0)
Phosphoadenosine
phosphosulfate
Adenosine
3',5'-
diphosphate
N-acetylneuraminyl-
Galactosylceramide
Sphinganine
Pyridoxal
5'-phosphate
Magnesium
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Magnesium
Calcium
Magnesium
Magnesium
Zinc
Calcium
Galabiosylceramide-
sulfate
Glycine and
Serine
Metabolism
Intracellular space
Endoplasmic Reticulum
Golgi complex
Golgi complex
Lysosome
Lysosome
Endoplasmic Reticulum