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Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Cytochrome P450
2C54
Cytochrome P450
2D9
Alcohol
dehydrogenase
[NADP(+)]
Short-chain
dehydrogenase/reductase
family 16C
member 6
Alcohol
dehydrogenase
[NADP(+)]
Steroid
21-hydroxylase
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
2D9
3-beta-HSD 1
Steroid
21-hydroxylase
3-beta-HSD 1
Cytochrome P450
2C54
Steroid
21-hydroxylase
Cytochrome P450
2D9
Cytochrome P450
2D9
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
3-beta-HSD 1
3-beta-HSD 1
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
Cytochrome P450
2C39
1,25-
dihydroxyvitamin
D(3)
24-hydroxylase,
mitochondrial
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Cytochrome P450
2D9
Alcohol
dehydrogenase
[NADP(+)]
Alcohol
dehydrogenase
[NADP(+)]
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Short-chain
dehydrogenase/reductase
family 42E
member 1
Cholesterol
Progesterone
Progesterone
11b,21-Dihydroxy-3,20-oxo-
5b-pregnan-18-al
NADPH
3a,11b,21-Trihydroxy-20-oxo-
5b-pregnan-18-al
NADP
NADP
Dissipation
Aldosterone
NADPH
Accumulation
18-Hydroxycorticosterone
O
2
H
2
O
Corticosterone
O
2
H
2
O
11b,21-Dihydroxy-5b-
pregnane-3,20-dione
Tetrahydrocorticosterone
NADP
NADPH
11-Dehydrocorticosterone
21-Hydroxy-5b-pregnane-
3,11,20-trione
NADP
3a,21-Dihydroxy-5b-pregnane-
11,20-dione
NADPH
NADP
NADPH
11b-Hydroxyprogesterone
21-Deoxycortisol
Cortisol
Deoxycorticosterone
21-Hydroxypregnenolone
NAD
NADH
Pregnenolone
NAD
NADH
17-Hydroxyprogesterone
Cortexolone
17a-Hydroxypregnenolone
NAD
NADH
NADH
17α,21-Dihydroxypregnenolone
NAD
20a,22b-Dihydroxycholesterol
4-
Methylpentanal
17a,20a-Dihydroxycholesterol
22b-Hydroxycholesterol
20α-Hydroxycholesterol
17a,21-Dihydroxy-5b-
pregnane-3,11,20-trione
NADP
Cortisone
NADPH
Tetrahydrocortisone
NADP
NADPH
Dihydrocortisol
NADP
NADPH
Tetrahydrocortisol
NADP
NADPH
O
2
11b,17a,21-Trihydroxypreg-
nenolone
H
2
O
NADPH
5a-Pregnane-3,20-dione
NADP
3a-Hydroxy-5b-pregnane-20-one
NADP
NADPH
NADP
NADPH
Heme
Heme
Heme
Heme
Heme
Heme