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5- aminolevulinate synthase, nonspecific, mitochondrial 5- aminolevulinate synthase, nonspecific, mitochondrial Dehydrogenase/reductase SDR family member 7B Sphingosine kinase 1 Sphingosine- 1-phosphate phosphatase 1 Phospholipid phosphatase 1 Sphingosine- 1-phosphate lyase 1 Sphingolipid delta(4)- desaturase/C4- monooxygenase DES2 Sphingosine- 1-phosphate lyase 1 Sphingosine kinase 1 Sphingosine- 1-phosphate phosphatase 1 Phospholipid phosphatase 1 Alkaline ceramidase Sphingosine kinase 1 Phospholipid phosphatase 1 Sphingosine- 1-phosphate phosphatase 1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 2- hydroxyacylsphingosine 1-beta- galactosyltransferase Galactosylceramidase Glucosylceramidase Ceramide glucosyltransferase Unknown Beta-1,4- galactosyltransferase 6 Galactose-3- O- sulfotransferase 1 Arylsulfatase G Alpha-N- acetylgalactosaminidase Galactose-3- O- sulfotransferase 1 Sialidase-3 Alkaline ceramidase 3 L-Serine Palmityl-CoA 3-Dehydrosphinganine Sphinganine NADPH NADP ATP ADP Sphinganine 1-phosphate ADP ATP Pi O- Phosphoethanolamine Dihydroceramide Ceramide (d18:1/18:0) Sphingosine 1-phosphate Sphingosine ATP ADP ADP ATP Pi ATP CerP(d18:1/12:0) ADP Pi SM(d18:1/18:0) Accumulation Galactosylceramide (d18:1/16:0) Glucosylceramide Lactosylceramide (d18:1/12:0) Phosphoadenosine phosphosulfate 3-O-Sulfogalactosylceramide (d18:1/24:0) Adenosine 3',5'- diphosphate H2O Sulfate D-Galactose Galabiosylceramide (d18:1/22:0) Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate N-acetylneuraminyl- Galactosylceramide Sphinganine Pyridoxal 5'-phosphate Magnesium Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Magnesium Calcium Magnesium Magnesium Zinc Calcium Galabiosylceramide- sulfate Glycine and Serine Metabolism Intracellular space Endoplasmic Reticulum Golgi complex Golgi complex Lysosome Lysosome Endoplasmic Reticulum