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Pathway Description
Lactic Acidemia
Rattus norvegicus
Category:
Metabolite Pathway
Sub-Category:
Disease
Created: 2018-09-10
Last Updated: 2019-08-16
Increased lactic acid concentrations in urine or serum can be a result of many metabolic disorders but also of other origin (infections, etc.). Respiratory chain defects account for most of the metabolic causes of lactic acid accumulation. Often alanine is also high. A urine spectrum indicating an increased lactic acid and alanine concentration is shown.
References
Lactic Acidemia References
Robinson BH: Lactic acidemia and mitochondrial disease. Mol Genet Metab. 2006 Sep-Oct;89(1-2):3-13. doi: 10.1016/j.ymgme.2006.05.015. Epub 2006 Jul 18.
Pubmed: 16854608
Alanine Metabolism References
Dignam JD, Dignam SS, Brumley LL: Alanyl-tRNA synthetase from Escherichia coli, Bombyx mori and Ratus ratus. Existence of common structural features. Eur J Biochem. 1991 May 23;198(1):201-10. doi: 10.1111/j.1432-1033.1991.tb16002.x.
Pubmed: 2040280
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
Ishiguro M, Suzuki M, Takio K, Matsuzawa T, Titani K: Complete amino acid sequence of rat liver cytosolic alanine aminotransferase. Biochemistry. 1991 Jun 18;30(24):6048-53. doi: 10.1021/bi00238a031.
Pubmed: 2043642
Lehn DA, Moran SM, MacDonald MJ: The sequence of the rat pyruvate carboxylase-encoding cDNA. Gene. 1995 Nov 20;165(2):331-2. doi: 10.1016/0378-1119(95)00557-m.
Pubmed: 8522203
Jitrapakdee S, Booker GW, Cassady AI, Wallace JC: Cloning, sequencing and expression of rat liver pyruvate carboxylase. Biochem J. 1996 Jun 1;316 ( Pt 2):631-7. doi: 10.1042/bj3160631.
Pubmed: 8687410
Oda T, Miyajima H, Suzuki Y, Ichiyama A: Nucleotide sequence of the cDNA encoding the precursor for mitochondrial serine:pyruvate aminotransferase of rat liver. Eur J Biochem. 1987 Nov 2;168(3):537-42. doi: 10.1111/j.1432-1033.1987.tb13451.x.
Pubmed: 2822418
Oda T, Nishiyama K, Ichiyama A: Characterization and sequence analysis of rat serine:pyruvate/alanine:glyoxylate aminotransferase gene. Genomics. 1993 Jul;17(1):59-65. doi: 10.1006/geno.1993.1283.
Pubmed: 8406472
Oda T, Funai T, Ichiyama A: Generation from a single gene of two mRNAs that encode the mitochondrial and peroxisomal serine:pyruvate aminotransferase of rat liver. J Biol Chem. 1990 May 5;265(13):7513-9.
Pubmed: 2332438
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000313
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