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Serine
hydroxymethyltransferase
Methylenetetrahydrofolate
reductase
Methionine
synthase
Cystathionine
gamma-lyase
Cystathionine
beta-synthase
Cystathionine
beta-synthase
Betaine--
homocysteine S-
methyltransferase
1
DNA
(cytosine-5)-
methyltransferase
1
S-
adenosylmethionine
decarboxylase
proenzyme
Spermidine
synthase
Purine
nucleoside
phosphorylase
Adenosylhomocysteinase
Betaine--
homocysteine S-
methyltransferase
1
Amine oxidase
[flavin-
containing] A
Methionyl-tRNA
synthetase
Methionyl-tRNA
formyltransferase,
mitochondrial
S-
adenosylmethionine
synthase
Choline
dehydrogenase,
mitochondrial
Methionine-R-
sulfoxide
reductase B2,
mitochondrial
Methionine-R-
sulfoxide
reductase B2,
mitochondrial
L-Homoserine
L-Cysteine
Homocysteine
Tetrahydrofolic acid
L-Serine
5,10-Methylene-THF
Glycine
5-Methyltetrahydrofolic acid
Accumulation
L-Methionine
L-Cystathionine
H
2
O
2-Ketobutyric
acid
L-Serine
H
2
O
L-Serine
H
2
O
S-Adenosylmethionine
Glycine
S-Adenosylhomocysteine
Sarcosine
S-Adenosylmethioninamine
CO
2
Putrescine
5'-Methylthioadenosine
Spermidine
P
i
5-Methylthioribose 1-phosphate
Accumulation
L-Methionine
Adenosine
βine
Dimethylglycine
H
2
O
O
2
2-Oxo-4-
methylthiobutanoic
acid
NH
3
H
2
O
2
ATP
AMP
PP
i
10-Formyltetrahydrofolate
Tetrahydrofolic acid
ATP
P
i
PP
i
Choline
Methionine
sulfoxide
Pyridoxal
5'-phosphate
FAD
Zinc (II) ion
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Zinc (II) ion
NAD
Zinc (II) ion
FAD
Magnesium
Potassium
FAD
Zinc
Zinc
Acceptor
Reduced
acceptor
oxidized
thioredoxin
reduced
thioredoxin
tRNA(Met)
L-
Methionyl-
tRNA(Met)
N-
formylmethionyl-
tRNA(fMet)
Glycine and
Serine
Metabolism
Cysteine
Metabolism
Sulfate/Sulfite
Metabolism
Intracellular space
Nucleus membrane
Mitochondria
Mitochondria