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Excitatory
amino acid
transporter 1
Excitatory
amino acid
transporter 1
Mitochondrial
ornithine
transporter 1
Mitochondrial
ornithine
transporter 1
Mitochondrial
glutamate
carrier 2
Alanine
aminotransferase
1
Glutaminase
liver isoform,
mitochondrial
Glutamate
dehydrogenase
1,
mitochondrial
Carbamoyl-
phosphate
synthase
[ammonia],
mitochondrial
Aspartate
aminotransferase,
mitochondrial
Ornithine
carbamoyltransferase,
mitochondrial
Arginase-1
Argininosuccinate
lyase
Argininosuccinate
synthase
Accumulation
L-Glutamine
Accumulation
L-Alanine
Oxoglutaric acid
L-Glutamic acid
Oxalacetic acid
Accumulation
NH
3
L-Aspartic acid
Fumaric acid
L-Arginine
Accumulation
Ornithine
Accumulation
L-Glutamine
Accumulation
L-Alanine
Accumulation
Ornithine
Dissipation
Citrulline
Dissipation
Citrulline
Accumulation
Ornithine
Accumulation
Ornithine
Dissipation
Citrulline
Dissipation
Citrulline
L-Aspartic acid
L-Glutamic acid
L-Glutamic acid
Pyruvic acid
H
2
O
H
2
O
NAD
Oxoglutaric acid
NADH
ATP
CO
2
H
2
O
ADP
P
i
Accumulation
Carbamoyl phosphate
P
i
H
2
O
Urea
Argininosuccinic acid
ATP
AMP
PP
i
Calcium
Pyridoxal
5'-phosphate
Pyridoxal
5'-phosphate
Manganese
Ammonia
Recycling
Pyrimidine
Metabolism
Glutamate
Metabolism
Alanine
Metabolism
Glucose-Alanine
Cycle
Selenoamino
Acid Metabolism
Malate-
Aspartate
Shuttle
Glutamate
Metabolism
Alanine
Metabolism
Glucose-Alanine
Cycle
Gluconeogenesis
Histidine
Metabolism
Porphyrin
Metabolism
Glucose-Alanine
Cycle
Porphyrin
Metabolism
Alanine
Metabolism
Ammonia
Recycling
Glutamate
Metabolism
Glucose-Alanine
Cycle
Ammonia
Recycling
Purine
Metabolism
Glucose-Alanine
Cycle
Aspartate
Metabolism
Citric Acid
Cycle
Arginine and
Proline
Metabolism
D-Arginine and
D-Ornithine
Metabolism
D-Arginine and
D-Ornithine
Metabolism
Cytosol
Mitochondria
Mitochondrial Matrix
Urea Cycle
Extracellular Space
Intracellular Space
Mitochondria
Slc1a3
Slc1a3
Slc25a15
Slc25a15
Slc25a18
Gpt
Gls2
Glud1
Cps1
Got2
Otc
Arg1
Asl
Ass1
Accumulation
L-Glutamine
Accumulation
L-Alanine
Oxoglutaric
acid
L-Glutamic acid
Oxalacetic acid
Accumulation
Ammonia
L-Aspartic acid
Fumaric acid
L-Arginine
Accumulation
Ornithine
Accumulation
L-Glutamine
Accumulation
L-Alanine
Accumulation
Ornithine
Dissipation
Citrulline
Dissipation
Citrulline
Accumulation
Ornithine
Accumulation
Ornithine
Dissipation
Citrulline
Dissipation
Citrulline
L-Aspartic acid
L-Glutamic acid
L-Glutamic acid
Pyruvic acid
Water
Water
NAD
Oxoglutaric
acid
NADH
Adenosine
triphosphate
Carbon dioxide
Water
Adenosine
diphosphate
Phosphoric acid
Accumulation
Carbamoyl
phosphate
Phosphate
Water
Urea
Argininosuccinic
acid
Adenosine
triphosphate
Adenosine
monophosphate
Pyrophosphate
Ammonia
Recycling
Pyrimidine
Metabolism
Glutamate
Metabolism
Alanine
Metabolism
Glucose-Alanine
Cycle
Selenoamino
Acid Metabolism
Malate-
Aspartate
Shuttle
Glutamate
Metabolism
Alanine
Metabolism
Glucose-Alanine
Cycle
Gluconeogenesis
Histidine
Metabolism
Porphyrin
Metabolism
Glucose-Alanine
Cycle
Porphyrin
Metabolism
Alanine
Metabolism
Ammonia
Recycling
Glutamate
Metabolism
Glucose-Alanine
Cycle
Ammonia
Recycling
Purine
Metabolism
Glucose-Alanine
Cycle
Aspartate
Metabolism
Citric Acid
Cycle
Arginine and
Proline
Metabolism
D-Arginine and
D-Ornithine
Metabolism
D-Arginine and
D-Ornithine
Metabolism