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Tyrosine
aminotransferase
Aspartate
aminotransferase,
cytoplasmic
4-
hydroxyphenylpyruvate
dioxygenase
Maleylacetoacetate
isomerase
Fumarylacetoacetase
Aromatic-L-
amino-acid
decarboxylase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Tyrosinase
Dopamine beta-
hydroxylase
Aromatic-L-
amino-acid
decarboxylase
Tyrosinase
Tyrosinase
Tyrosinase
Tyrosinase-
related protein
1
Tyrosinase
Phenylethanolamine
N-
methyltransferase
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Alcohol
dehydrogenase 1
Amine oxidase
[flavin-
containing] A
Amine oxidase
[flavin-
containing] A
3-
hydroxyanthranilate
3,4-dioxygenase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Homogentisate
1,
2-dioxygenase
Macrophage
migration
inhibitory
factor
Amiloride-
sensitive amine
oxidase
[copper-
containing]
Amine oxidase
[flavin-
containing] A
Tyrosinase
Catechol O-
methyltransferase
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Catechol O-
methyltransferase
Accumulation
L-Tyrosine
Oxoglutaric
acid
Accumulation
4-
Hydroxyphenylpyruvic
acid
L-Glutamic acid
L-Aspartic acid
Oxalacetic acid
O
2
Homogentisic
acid
CO
2
Maleylacetoacetic
acid
4-
Fumarylacetoacetic
acid
H
2
O
Acetoacetic
acid
Fumaric acid
Tyramine
CO
2
Homovanillin
NADP
H
2
O
Accumulation
p-
Hydroxyphenylacetic
acid
NADPH
O
2
Dopamine
H
2
O
Ascorbic acid
O
2
Norepinephrine
Dehydroascorbic
acid
H
2
O
L-Dopa
Tetrahydrobiopterin
4a-
Hydroxytetrahydrobiopterin
O
2
Dopaquinone
H
2
O
Leucodopachrome
L-Dopachrome
O
2
5,6-
Dihydroxyindole
H
2
O
O
2
Indole-5,6-
quinone
H
2
O
Melanin
5,6-
Dihydroxyindole-
2-carboxylic
acid
O
2
H
2
O
S-
Adenosylmethionine
S-
Adenosylhomocysteine
Epinephrine
H
2
O
O
2
3,4-
Dihydroxymandelaldehyde
NH
3
H
2
O
2
H
2
O
O
2
Methylamine
H
2
O
2
Normetanephrine
H
2
O
O
2
3-Methoxy-4-
hydroxyphenylglycolaldehyde
NH
3
H
2
O
2
Metanephrine
H
2
O
O
2
NH
3
H
2
O
2
NAD
H
2
O
3,4-
Dihydroxymandelic
acid
NADH
H
+
NAD
NADH
3,4-
Dihydroxyphenylglycol
Dopamine
H
2
O
O
2
3,4-
Dihydroxyphenylacetaldehyde
NH
3
H
2
O
2
3-
Methoxytyramine
H
2
O
O
2
Homovanillin
H
2
O
2
NH
3
NAD
H
2
O
3,4-
Dihydroxybenzeneacetic
acid
NADH
H
+
NAD
H
2
O
Homovanillic
acid
NADH
H
+
O
2
2-Hydroxy-3-
(4-
hydroxyphenyl)propenoic
acid
H
2
O
O
2
H
2
O
2