Homocystinuria, Cystathionine beta-Synthase Deficiency, also known as homocystinuria, is a inherited disorder of amino acid methionine metabolism caused by a defective cystathionine beta-Synthase. Cystathionine beta-Synthase catalyzes the conversion of homocysteine and L-Serine into L-Cystathionine which is the substrate of cystathionine gamma-lyase. This disorder is characterized by a large accumulation of homocysteine in the cell. Symptoms of the disorder include thromboembolism, ectopia lentis and/or severe myopia, skeletal system deficiency and developmental delay. Treatment with homocystinuria aims at correct the biochemical abnormalities through disorder management (e.g. surveillance, circumstances to avoid, prevention of primary manifestations, etc.

Homocystinuria, Cystathionine beta-Synthase Deficiency References

Homocysteine Degradation References