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Pathway Description
EPO Signaling Pathway
Mus musculus
Category:
Protein Pathway
Sub-Categories:
Cytokine Signaling
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The hormone erythropoietin, is a 166 amino acid protein with an apparent molecular weight in its native form of 39,000 Da. The molecule is heavily glycosylated since its mass derived from its amino acid content is 18,398. The selective interaction of a hormone with its target cells is usually mediated by cell membrane receptors specific for the particular hormone. Erythropoietin-responsive cells have a trypsin-sensitive receptor for the hormone which requires protein synthesis for its maintenance. Erythropoietin-responsive cells can interact with other hematopoietic growth factors, and such interactions may lead to competition for pathway-specific differentiation, particularly under conditions of high cell density. The amino-terminal region of the hormone is not involved in receptor binding.
References
EPO Signaling Pathway References
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Pubmed: 9528750
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Pubmed: 7720707
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Pubmed: 7568026
Chretien S, Duprez V, Maouche L, Gisselbrecht S, Mayeux P, Lacombe C: Abnormal erythropoietin (Epo) gene expression in the murine erythroleukemia IW32 cells results from a rearrangement between the G-protein beta2 subunit gene and the Epo gene. Oncogene. 1997 Oct 16;15(16):1995-9. doi: 10.1038/sj.onc.1201364.
Pubmed: 9365246
Shoemaker CB, Mitsock LD: Murine erythropoietin gene: cloning, expression, and human gene homology. Mol Cell Biol. 1986 Mar;6(3):849-58. doi: 10.1128/mcb.6.3.849.
Pubmed: 3773894
McDonald JD, Lin FK, Goldwasser E: Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol. 1986 Mar;6(3):842-8. doi: 10.1128/mcb.6.3.842.
Pubmed: 3022133
D'Andrea AD, Lodish HF, Wong GG: Expression cloning of the murine erythropoietin receptor. Cell. 1989 Apr 21;57(2):277-85. doi: 10.1016/0092-8674(89)90965-3.
Pubmed: 2539263
Kuramochi S, Ikawa Y, Todokoro K: Characterization of murine erythropoietin receptor genes. J Mol Biol. 1990 Dec 5;216(3):567-75. doi: 10.1016/0022-2836(90)90384-x.
Pubmed: 2175360
Hino M, Tojo A, Misawa Y, Morii H, Takaku F, Shibuya M: Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line. Mol Cell Biol. 1991 Nov;11(11):5527-33. doi: 10.1128/mcb.11.11.5527.
Pubmed: 1656233
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Pubmed: 15489334
Dupont G, McGuinness OM, Johnson MH, Berridge MJ, Borgese F: Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking. Biochem J. 1996 Jun 1;316 ( Pt 2):583-91. doi: 10.1042/bj3160583.
Pubmed: 8687404
Reith AD, Ellis C, Lyman SD, Anderson DM, Williams DE, Bernstein A, Pawson T: Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J. 1991 Sep;10(9):2451-9.
Pubmed: 1714377
Silvennoinen O, Witthuhn BA, Quelle FW, Cleveland JL, Yi T, Ihle JN: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8429-33. doi: 10.1073/pnas.90.18.8429.
Pubmed: 8378315
Nakamura N, Chin H, Miyasaka N, Miura O: An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells. J Biol Chem. 1996 Aug 9;271(32):19483-8. doi: 10.1074/jbc.271.32.19483.
Pubmed: 8702638
Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN: Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95. doi: 10.1016/s0092-8674(00)81167-8.
Pubmed: 9590173
Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G: New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep;24(9):1552-64. doi: 10.1359/jbmr.090417.
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Pubmed: 1732748
Matthews RJ, Bowne DB, Flores E, Thomas ML: Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol. 1992 May;12(5):2396-405. doi: 10.1128/mcb.12.5.2396.
Pubmed: 1373816
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0069678
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