Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Lectin-Induced Complement Pathway
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Immunological
Pathogen-Activated Signaling
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The lectin-induced complement pathway, also known as the MBL pathway, is a complement activation pathway that is triggered by mannose-binding lectin binding to sugars found on carbohydrates found on pathogens. Unlike other complement pathways, this pathways components do not bind directly to the antibodies attached to the pathogen. The bacteria that MBL binds to include listeria, salmonella, and HIV-1.
References
Lectin-Induced Complement Pathway References
Smith MA, Gerrie LM, Dunbar B, Fothergill JE: Primary structure of bovine complement activation fragment C4a, the third anaphylatoxin. Purification and complete amino acid sequence. Biochem J. 1982 Nov 1;207(2):253-60. doi: 10.1042/bj2070253.
Pubmed: 6760852
Fredslund F, Jenner L, Husted LB, Nyborg J, Andersen GR, Sottrup-Jensen L: The structure of bovine complement component 3 reveals the basis for thioester function. J Mol Biol. 2006 Aug 4;361(1):115-27. doi: 10.1016/j.jmb.2006.06.009. Epub 2006 Jun 21.
Pubmed: 16831446
Huemer HP, Larcher C, van Drunen Littel-van den Hurk S, Babiuk LA: Species selective interaction of Alphaherpesvirinae with the "unspecific" immune system of the host. Arch Virol. 1993;130(3-4):353-64. doi: 10.1007/bf01309666.
Pubmed: 8390825
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063898
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings