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Peptidoglycan recognition protein 1 Monocyte differentiation antigen CD14 Toll-like receptor 2 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 TNF receptor- associated factor 6 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Aurora kinase A Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator NF-kappa-B inhibitor zeta NF-kappaB transcription factor p65 subunit NF-kappa-B inhibitor zeta NF-kappa-B inhibitor zeta Monocyte differentiation antigen CD14 Toll-like receptor 4 Lymphocyte antigen 96 Toll- interacting protein Mitogen- activated protein kinase kinase kinase 13 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 TIR domain containing adaptor protein Mitogen- activated protein kinase kinase kinase 7 TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP1 protein Mitogen- activated protein kinase 13 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Aurora kinase A Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 13 Mitogen- activated protein kinase 13 Proto-oncogene c-Fos Transcription factor AP-1 ETS translocation variant 1 Peroxisome proliferator- activated receptor gamma NF-kappa-B inhibitor zeta Toll-like receptor 9 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 Toll-like receptor 3 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 Toll-like receptor 9 Myeloid differentiation primary response protein MyD88 Interleukin-1 receptor- associated kinase 1 NF-kappa-B inhibitor zeta Mitogen- activated protein kinase 13 Pi Pi Pi Pro-inflammatory cytokines (IL12, IL1, TNF-a) oxidized EPA oxidized EPA Lipoproteins (BLP, PGN, LAM, Mannans) Lipopolysaccharides (LPS) Apoptosis of host cells Influence adaptive immune system T cells Cell-mediated immunity Direct antimicrobial response speculated CpG DNA Poly (I:c) Imiquimod, R848 Extracellular Cytoplasm of Monocytes/Macrophages, Dendritic cells, Intestinal Epithelial & Endothelial cells
Nucleus PGLYRP1 CD14 TLR2 MYD88 IRAK1 TRAF6 ECSIT AURKA CHUK IKBKB IKBKG NFKBIZ RELA NFKBIZ NFKBIZ CD14 TLR4 LY96 TOLLIP MAP3K13 MYD88 IRAK1 TIRAP MAP3K7 TAB2 MAP3K7IP1 MAPK13 MAP2K6 MAP2K6 MAP2K6 AURKA MAP2K6 MAPK13 MAPK13 FOS JUN ETV1 PPARG NFKBIZ TLR9 MYD88 IRAK1 TLR3 MYD88 IRAK1 TLR9 MYD88 IRAK1 NFKBIZ MAPK13 Phosphate Phosphate Phosphate
PGLYRP1 CD14 TLR2 MYD88 IRAK1 TRAF6 ECSIT AURKA CHUK IKBKB IKBKG NFKBIZ RELA NFKBIZ NFKBIZ CD14 TLR4 LY96 TOLLIP MAP3K13 MYD88 IRAK1 TIRAP MAP3K7 TAB2 MAP3K7IP1 MAPK13 MAP2K6 MAP2K6 MAP2K6 AURKA MAP2K6 MAPK13 MAPK13 FOS JUN ETV1 PPARG NFKBIZ TLR9 MYD88 IRAK1 TLR3 MYD88 IRAK1 TLR9 MYD88 IRAK1 NFKBIZ MAPK13 Pi Pi Pi Pro-inflammatory cytokines (IL12, IL1, TNF-a) oxidized EPA oxidized EPA Lipoproteins (BLP, PGN, LAM, Mannans) Lipopolysaccharides (LPS) Apoptosis of host cells Influence adaptive immune system T cells Cell-mediated immunity Direct antimicrobial response speculated CpG DNA Poly (I:c) Imiquimod, R848 Extracellular Cytoplasm of Monocytes/Macrophages, Dendritic cells, Intestinal Epithelial & Endothelial cells
Nucleus PGLYRP1 CD14 TLR2 MYD88 IRAK1 TRAF6 ECSIT AURKA CHUK IKBKB IKBKG NFKBIZ RELA NFKBIZ NFKBIZ CD14 TLR4 LY96 TOLLIP MAP3K13 MYD88 IRAK1 TIRAP MAP3K7 TAB2 MAP3K7IP1 MAPK13 MAP2K6 MAP2K6 MAP2K6 AURKA MAP2K6 MAPK13 MAPK13 FOS JUN ETV1 PPARG NFKBIZ TLR9 MYD88 IRAK1 TLR3 MYD88 IRAK1 TLR9 MYD88 IRAK1 NFKBIZ MAPK13 Pi Pi Pi