PathBank

Pathway Description

Classical Complement Pathway

Bos taurus

Category:

Protein Pathway

Sub-Categories:

Immunological

Cellular Response

Created: 2018-09-20

Last Updated: 2019-08-16

The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death.

References

Classical Complement Pathway References

Smith MA, Gerrie LM, Dunbar B, Fothergill JE: Primary structure of bovine complement activation fragment C4a, the third anaphylatoxin. Purification and complete amino acid sequence. Biochem J. 1982 Nov 1;207(2):253-60. doi: 10.1042/bj2070253.

Pubmed: 6760852

Fredslund F, Jenner L, Husted LB, Nyborg J, Andersen GR, Sottrup-Jensen L: The structure of bovine complement component 3 reveals the basis for thioester function. J Mol Biol. 2006 Aug 4;361(1):115-27. doi: 10.1016/j.jmb.2006.06.009. Epub 2006 Jun 21.

Pubmed: 16831446

Huemer HP, Larcher C, van Drunen Littel-van den Hurk S, Babiuk LA: Species selective interaction of Alphaherpesvirinae with the "unspecific" immune system of the host. Arch Virol. 1993;130(3-4):353-64. doi: 10.1007/bf01309666.

Pubmed: 8390825

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0064047

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Visualize Compound Data

		Calcium
		Magnesium

Visualize Protein Data

		Complement C1q subcomponent subunit A
		Complement C1q subcomponent subunit B
		Complement C1s subcomponent
		Complement C2
		Complement C3
		Complement C4
		Complement component C6
		Complement component C7
		Complement component C9