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Pathway Description
g-Secretase Mediated ErbB4 Signalling Pathway
Bos taurus
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The HER4/erbB4-encoded protein, is a transmembrane receptor that contains a cytoplasmic tyrosine kinase domain. This domain exhibits almost 80 percent homologness with the corresponding domain of EGFR (the epidermal growth factor receptor). It was discovered in the 1990s by Plowman et al, that heregulin was responsible for inducing tyrosine phosphorylation of HER4/erbB4.
ErbB4 (HER4) receptor is classified as type I GFRs. Where the tyrosine kinase growth factor receptors (GFRs) have been sub-classified into 9 different families based on the structure of their extracellular ligand binding and intracellular kinase domains and the manner in which such protein induce the ligands.
Experiments revealed that erbB4 has is readily findable in heart, spleen, breast, muscle, pituitary, kidney, parathyroid, brain, and testis.
References
g-Secretase Mediated ErbB4 Signalling Pathway References
Yang W, Cerione RA: Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain. J Biol Chem. 1997 Oct 3;272(40):24819-24. doi: 10.1074/jbc.272.40.24819.
Pubmed: 9312079
Lin Q, Lo CG, Cerione RA, Yang W: The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem. 2002 Mar 22;277(12):10134-8. doi: 10.1074/jbc.M110329200. Epub 2002 Jan 17.
Pubmed: 11799118
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.
Pubmed: 19393038
Anders A, Gilbert S, Garten W, Postina R, Fahrenholz F: Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases. FASEB J. 2001 Aug;15(10):1837-9. doi: 10.1096/fj.01-0007fje.
Pubmed: 11481247
Haining EJ, Yang J, Bailey RL, Khan K, Collier R, Tsai S, Watson SP, Frampton J, Garcia P, Tomlinson MG: The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J Biol Chem. 2012 Nov 16;287(47):39753-65. doi: 10.1074/jbc.M112.416503. Epub 2012 Oct 3.
Pubmed: 23035126
Howard L, Lu X, Mitchell S, Griffiths S, Glynn P: Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Biochem J. 1996 Jul 1;317 ( Pt 1):45-50. doi: 10.1042/bj3170045.
Pubmed: 8694785
Parker PJ, Coussens L, Totty N, Rhee L, Young S, Chen E, Stabel S, Waterfield MD, Ullrich A: The complete primary structure of protein kinase C--the major phorbol ester receptor. Science. 1986 Aug 22;233(4766):853-9. doi: 10.1126/science.3755547.
Pubmed: 3755547
Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988 Aug 25;334(6184):661-5. doi: 10.1038/334661a0.
Pubmed: 3045562
Cazaubon SM, Parker PJ: Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. J Biol Chem. 1993 Aug 15;268(23):17559-63.
Pubmed: 8349635
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0089975
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