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Pathway Description
EGF Signalling Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Growth Factor
Gene Regulatory
Kinase Signaling
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
Epidermal growth factor (EGF) is a potent polypeptide mitogen that initiates its biological activity by interacting with the cell surface. The E G F receptors are both transmembrane proteins with cytosolically exposed tyrosine specific protein kinases which are stimulated by ligand binding. Current data strongly suggests that these kinases are causally linked to many if not all of the biological activities of the EGF receptors. Transmembrane signalling is the result of a composite of ligand-receptor interactions in the endosome (stimulation) and modifications of the primary or quaternary structure of the receptor (activation).
References
EGF Signalling Pathway References
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Pubmed: 1524680
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Pubmed: 3387228
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Pubmed: 3666147
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Pubmed: 9566962
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Pubmed: 3755379
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Pubmed: 2428667
Housey GM, Johnson MD, Hsiao WL, O'Brian CA, Murphy JP, Kirschmeier P, Weinstein IB: Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell. 1988 Feb 12;52(3):343-54. doi: 10.1016/s0092-8674(88)80027-8.
Pubmed: 3345563
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Pubmed: 15057822
Park JB, Kim EJ, Yang EJ, Seo SR, Chung KC: JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses neuronal differentiation. J Neurochem. 2007 Jan;100(2):555-66. doi: 10.1111/j.1471-4159.2006.04263.x. Epub 2006 Nov 29.
Pubmed: 17156131
Marquardt B, Stabel S: Sequence of a rat cDNA encoding the ERK1-MAP kinase. Gene. 1992 Oct 21;120(2):297-9. doi: 10.1016/0378-1119(92)90109-3.
Pubmed: 1327976
Yung Y, Yao Z, Hanoch T, Seger R: ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. J Biol Chem. 2000 May 26;275(21):15799-808. doi: 10.1074/jbc.M910060199.
Pubmed: 10748187
Boulton TG, Yancopoulos GD, Gregory JS, Slaughter C, Moomaw C, Hsu J, Cobb MH: An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science. 1990 Jul 6;249(4964):64-7. doi: 10.1126/science.2164259.
Pubmed: 2164259
Duhe RJ, Rui H, Greenwood JD, Garvey K, Farrar WL: Cloning of the gene encoding rat JAK2, a protein tyrosine kinase. Gene. 1995 Jun 9;158(2):281-5. doi: 10.1016/0378-1119(95)00041-4.
Pubmed: 7607555
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Ripperger JA, Fritz S, Richter K, Hocke GM, Lottspeich F, Fey GH: Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J Biol Chem. 1995 Dec 15;270(50):29998-30006. doi: 10.1074/jbc.270.50.29998.
Pubmed: 8530402
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
Kwon H, Jeong K, Hwang EM, Park JY, Hong SG, Choi WS, Pak Y: Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin. Biochim Biophys Acta. 2009 Jul;1793(7):1325-33. doi: 10.1016/j.bbamcr.2009.04.015. Epub 2009 May 7.
Pubmed: 19427337
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0063810
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