PathBank

Pathway Description

Ubiquitin–Proteasome Pathway

Rattus norvegicus

Category:

Protein Pathway

Sub-Categories:

Transport/Degradation

Cellular Response

Created: 2018-09-20

Last Updated: 2019-08-16

The ubiquitin-proteasome pathway is the pathway in which molecules, specifically proteins, are broken down into smaller molecules in the cytosol or in the nucleus.This pathway subsequently has effects in many other pathways and processes. This pathway uses 2 distinct steps. The first step is that the protein being broken down is tagged by multiple ubiquitin units attaching to the protein. The second step is that the protein that has been tagged degrades as it is catalyzed by the 26S proteasome. This pathway is important for DNA repair, regulating the amount of proteins, and the creation of antigen-peptide.

References

Ubiquitin–Proteasome Pathway References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.

Pubmed: 15489334

Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.

Pubmed: 22673903

Hayashi T, Noga M, Matsuda M: Nucleotide sequence and expression of the rat polyubiquitin mRNA. Biochim Biophys Acta. 1994 Jun 21;1218(2):232-4. doi: 10.1016/0167-4781(94)90020-5.

Pubmed: 8018730

Hubbard MJ, Carne A: Differential feeding-related regulation of ubiquitin and calbindin9kDa in rat duodenum. Biochim Biophys Acta. 1994 Jul 6;1200(2):191-6. doi: 10.1016/0304-4165(94)90135-x.

Pubmed: 8031840

Hurt P, Walter L, Sudbrak R, Klages S, Muller I, Shiina T, Inoko H, Lehrach H, Gunther E, Reinhardt R, Himmelbauer H: The genomic sequence and comparative analysis of the rat major histocompatibility complex. Genome Res. 2004 Apr;14(4):631-9. doi: 10.1101/gr.1987704.

Pubmed: 15060004

Grou CP, Carvalho AF, Pinto MP, Wiese S, Piechura H, Meyer HE, Warscheid B, Sa-Miranda C, Azevedo JE: Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. J Biol Chem. 2008 May 23;283(21):14190-7. doi: 10.1074/jbc.M800402200. Epub 2008 Mar 22.

Pubmed: 18359941

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0063816

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine monophosphate
		Adenosine triphosphate

Visualize Protein Data

		26S proteasome non-ATPase regulatory subunit 13
		26S proteasome regulatory subunit 4
		26S proteasome regulatory subunit 6A
		26S proteasome regulatory subunit 6B
		26S proteasome regulatory subunit 7
		26S proteasome regulatory subunit 8
		26S proteasome subunit S5a
		Polyubiquitin-B
		Polyubiquitin-C
		Proteasome subunit alpha type-1
		Proteasome subunit alpha type-2
		Proteasome subunit alpha type-3
		Proteasome subunit alpha type-4
		Proteasome subunit alpha type-5
		Proteasome subunit alpha type-6
		Proteasome subunit alpha type-7
		Proteasome subunit beta type-1
		Proteasome subunit beta type-2
		Proteasome subunit beta type-3
		Proteasome subunit beta type-4
		Proteasome subunit beta type-5
		Proteasome subunit beta type-6
		Proteasome subunit beta type-7
		Small glutamine-rich tetratricopeptide repeat-containing protein beta
		Ubiquitin D
		Ubiquitin-conjugating enzyme E2 D1
		Ubiquitin-like modifier-activating enzyme 1