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Pathway Description
Classical Complement Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Immunological
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death.
References
Classical Complement Pathway References
Fimmel CJ, Brown KE, O'Neill R, Kladney RD: Complement C4 protein expression by rat hepatic stellate cells. J Immunol. 1996 Sep 15;157(6):2601-9.
Pubmed: 8805663
Cui L, Ferreri K, Hugli TE: Structural characterization of the C4a anaphylatoxin from rat. Mol Immunol. 1988 Jul;25(7):663-71. doi: 10.1016/0161-5890(88)90101-0.
Pubmed: 3262196
Walter L, Hurt P, Himmelbauer H, Sudbrak R, Gunther E: Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Immunogenetics. 2002 Jul;54(4):268-75. doi: 10.1007/s00251-002-0460-x. Epub 2002 Jun 14.
Pubmed: 12136338
Ide H, Itoh H, Tomita M, Murakumo Y, Kobayashi T, Maruyama H, Osada Y, Nawa Y: cDNA sequencing and expression of rat mast cell tryptase. J Biochem. 1995 Jul;118(1):210-5. doi: 10.1093/oxfordjournals.jbchem.a124880.
Pubmed: 8537314
Lutzelschwab C, Pejler G, Aveskogh M, Hellman L: Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. J Exp Med. 1997 Jan 6;185(1):13-29. doi: 10.1084/jem.185.1.13.
Pubmed: 8996238
Misumi Y, Sohda M, Ikehara Y: Nucleotide and deduced amino acid sequence of rat complement C3. Nucleic Acids Res. 1990 Apr 25;18(8):2178. doi: 10.1093/nar/18.8.2178.
Pubmed: 2336397
Nakagawa H, Komorita N: Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation. Biochem Biophys Res Commun. 1993 Aug 16;194(3):1181-7. doi: 10.1006/bbrc.1993.1947.
Pubmed: 8352775
Jacobs JW, Rubin JS, Hugli TE, Bogardt RA, Mariz IK, Daniels JS, Daughaday WH, Bradshaw RA: Purification, characterization, and amino acid sequence of rat anaphylatoxin (C3a). Biochemistry. 1978 Nov 14;17(23):5031-8. doi: 10.1021/bi00616a027.
Pubmed: 309768
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0064047
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