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Pathway Description
Stat3 Signaling Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Cytokine Signaling
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The STAT3 signalling pathway is a pathway activated by many different cytokines. It has also been found to be activated by many carcinogens. Cytokines are small proteins. These proteins are released by some of the cells in the immune system, and are vital to signalling pathways in the body of mammals. STAT3 is very important in the activation of the expression of certain mediators in the liver. STAT3 binds at the phosphotyrosine receptor which in turn phosphorylates tyrosine 705 at the C-terminal domain of STAT3, activating STAT3. If a receptor is missing tyrosine-kinase activity it will find tyrosine-kinases that are associated to the receptor, including JAK and Src when it is time for ligand engagement. Thanks to this recruitment, STAT3 is phosphorylated through the tyrosine phosphorylation cascade. This means that STAT3 is now activated, and its compounds disconnect from the receptor site, and relocate to the nucleus. Once there, the compounds bind to DNA response elements, and take part in many processes against target genes, such as apoptosis and cell proliferation, regulating their transcription.
References
Stat3 Signaling Pathway References
Ripperger JA, Fritz S, Richter K, Hocke GM, Lottspeich F, Fey GH: Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J Biol Chem. 1995 Dec 15;270(50):29998-30006. doi: 10.1074/jbc.270.50.29998.
Pubmed: 8530402
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Pubmed: 15489334
Kwon H, Jeong K, Hwang EM, Park JY, Hong SG, Choi WS, Pak Y: Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin. Biochim Biophys Acta. 2009 Jul;1793(7):1325-33. doi: 10.1016/j.bbamcr.2009.04.015. Epub 2009 May 7.
Pubmed: 19427337
Duhe RJ, Rui H, Greenwood JD, Garvey K, Farrar WL: Cloning of the gene encoding rat JAK2, a protein tyrosine kinase. Gene. 1995 Jun 9;158(2):281-5. doi: 10.1016/0378-1119(95)00041-4.
Pubmed: 7607555
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, Abraham RT: Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995 Jan 13;270(2):815-22. doi: 10.1074/jbc.270.2.815.
Pubmed: 7822316
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH: RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 1994 Jul 15;78(1):35-43. doi: 10.1016/0092-8674(94)90570-3.
Pubmed: 7518356
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7. doi: 10.1073/pnas.95.4.1432.
Pubmed: 9465032
Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD: ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 1991 May 17;65(4):663-75. doi: 10.1016/0092-8674(91)90098-j.
Pubmed: 2032290
Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG: Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6142-6. doi: 10.1073/pnas.88.14.6142.
Pubmed: 1712480
Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, Lawrence JC Jr: PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science. 1994 Oct 28;266(5185):653-6. doi: 10.1126/science.7939721.
Pubmed: 7939721
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0067587
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