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Pathway Description
g-Secretase Mediated ErbB4 Signalling Pathway
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Cellular Response
Created: 2018-09-20
Last Updated: 2019-08-16
The HER4/erbB4-encoded protein, is a transmembrane receptor that contains a cytoplasmic tyrosine kinase domain. This domain exhibits almost 80 percent homologness with the corresponding domain of EGFR (the epidermal growth factor receptor). It was discovered in the 1990s by Plowman et al, that heregulin was responsible for inducing tyrosine phosphorylation of HER4/erbB4.
ErbB4 (HER4) receptor is classified as type I GFRs. Where the tyrosine kinase growth factor receptors (GFRs) have been sub-classified into 9 different families based on the structure of their extracellular ligand binding and intracellular kinase domains and the manner in which such protein induce the ligands.
Experiments revealed that erbB4 has is readily findable in heart, spleen, breast, muscle, pituitary, kidney, parathyroid, brain, and testis.
References
g-Secretase Mediated ErbB4 Signalling Pathway References
Hellyer NJ, Kim HH, Greaves CH, Sierke SL, Koland JG: Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein. Gene. 1995 Nov 20;165(2):279-84. doi: 10.1016/0378-1119(95)00436-a.
Pubmed: 8522190
Carroll SL, Miller ML, Frohnert PW, Kim SS, Corbett JA: Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. J Neurosci. 1997 Mar 1;17(5):1642-59.
Pubmed: 9030624
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, Kelly RA: Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem. 1998 Apr 24;273(17):10261-9. doi: 10.1074/jbc.273.17.10261.
Pubmed: 9553078
Gambarotta G, Garzotto D, Destro E, Mautino B, Giampietro C, Cutrupi S, Dati C, Cattaneo E, Fasolo A, Perroteau I: ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration. J Biol Chem. 2004 Nov 19;279(47):48808-16. doi: 10.1074/jbc.M408374200. Epub 2004 Sep 8.
Pubmed: 15355992
Lai C, Lemke G: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991 May;6(5):691-704. doi: 10.1016/0896-6273(91)90167-x.
Pubmed: 2025425
Higashiyama S, Horikawa M, Yamada K, Ichino N, Nakano N, Nakagawa T, Miyagawa J, Matsushita N, Nagatsu T, Taniguchi N, Ishiguro H: A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. J Biochem. 1997 Sep;122(3):675-80. doi: 10.1093/oxfordjournals.jbchem.a021806.
Pubmed: 9348101
Chang H, Riese DJ 2nd, Gilbert W, Stern DF, McMahan UJ: Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature. 1997 May 29;387(6632):509-12. doi: 10.1038/387509a0.
Pubmed: 9168114
Tsuchiya T, Osaki T, Minamino N, Sasaki K: Peptidomics for Studying Limited Proteolysis. J Proteome Res. 2015 Nov 6;14(11):4921-31. doi: 10.1021/acs.jproteome.5b00820. Epub 2015 Oct 22.
Pubmed: 26479776
Taniguchi T, Hashimoto T, Taniguchi R, Shimada K, Kawamata T, Yasuda M, Nakai M, Terashima A, Koizumi T, Maeda K, Tanaka C: Cloning of the cDNA encoding rat Presenilin-1. Gene. 1997 Feb 20;186(1):73-5. doi: 10.1016/s0378-1119(96)00683-x.
Pubmed: 9047347
Takahashi H, Murayama M, Takashima A, Mercken M, Nakazato Y, Noguchi K, Imahori K: Molecular cloning and expression of the rat homologue of presenilin-1. Neurosci Lett. 1996 Mar 15;206(2-3):113-6. doi: 10.1016/s0304-3940(96)12449-6.
Pubmed: 8710164
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. doi: 10.1101/gr.2596504.
Pubmed: 15489334
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0089975
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