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(R)-lipoic acid
Probable fumarate
hydratase,
mitochondrial
Probable malate
dehydrogenase,
mitochondrial
Isocitrate
dehydrogenase
[NADP]
Isocitrate
dehydrogenase
[NADP]
Probable
cytoplasmic
aconitate
hydratase
Probable
cytoplasmic
aconitate
hydratase
Probable
ATP-citrate
synthase
Probable citrate
synthase,
mitochondrial
Probable
isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Probable
isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Pyruvate
carboxylase 1
Phosphoenolypyruvate
CarboxyKinase
Succinate--CoA
ligase
[ADP/GDP-forming]
subunit alpha,
mitochondrial
Succinate--CoA
ligase
[GDP-forming]
subunit beta,
mitochondrial
2-oxoglutarate
dehydrogenase,
mitochondrial
Pyruvate
dehydrogenase E1
component subunit
beta,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Dihydrolipoyllysine-
residue
acetyltransferase
component of
pyruvate
dehydrogenase
complex,
mitochondrial
DihydroLipoamide
S-
SuccinylTransferase
Dihydrolipoyl
dehydrogenase,
mitochondrial
Dihydrolipoyl
dehydrogenase,
mitochondrial
Phosphoenolpyruvic
acid
Pyruvic acid
Oxoglutaric acid
Succinyl-CoA
Fumaric acid
Oxalacetic acid
Acetyl-CoA
L-Malic acid
H
2
O
NAD
NADH
Hydrogen Ion
Isocitric acid
NADP
Oxalosuccinic
acid
NADPH
Hydrogen Ion
CO
2
cis-Aconitic acid
H
2
O
Citric acid
CoA
H
2
O
NAD
CO
2
NADH
Hydrogen Ion
ATP
HCO
3
-
ADP
P
i
GTP
GDP
CO
2
GTP
Succinic acid
CoA
GDP
P
i
CO
2
S-
Acetyldihydrolipoamide-
E
CO
2
Quinone
Hydroquinone
CoA
CoA
NAD
NADH
Hydrogen Ion
NAD
NADH
Hydrogen Ion
Magnesium
FAD
Probable pyruvate
dehydrogenase E1
component subunit
alpha,
mitochondrial
Lipoamide-E
S-
Succinyldihydrolipoamide-
E
Lipoamide-E
Dihydrolipoamide-
E
Dihydrolipoamide-
E
Glycolysis /
Gluconeogenesis
Arginine
Biosynthesis
Ascorbate and
aldarate
metabolism
Alanine,
aspartate and
glutamate
metabolism
D-Gln & D-Glu
metabolism
Val, Leu & Ile
degradation
Tyrosine
metabolism
Arginine
Biosynthesis
Alanine,
aspartate and
glutamate
metabolism
Glyoxylate and
dicarboxylate
metabolism
Fatty acid
biosynthesis
Fatty acid
elongation in
mitochondria
Val, Leu & Ile
degradation
Fatty acid
metabolism
Mitochondria
Cytosol
Mitochondria
fum-1
mdh-2
idh-1
idh-1
aco-1
aco-1
acly-1
Unknown
idha-1
idhb-1
pyc-1
pck-2
sucl-1
sucg-1
ogdh-1
pdhb-1
sdha-1
dlat-1
dlst-1
dld-1
dld-1
Phosphoenolpyruvic
acid
Pyruvic acid
Oxoglutaric acid
Succinyl-CoA
Fumaric acid
Oxalacetic acid
Acetyl-CoA
L-Malic acid
Water
NAD
NADH
Hydrogen Ion
Isocitric acid
NADP
Oxalosuccinic
acid
NADPH
Hydrogen Ion
Carbon dioxide
cis-Aconitic acid
Water
Citric acid
Coenzyme A
Water
NAD
Carbon dioxide
NADH
Hydrogen Ion
Adenosine
triphosphate
Hydrogen
carbonate
Adenosine
diphosphate
Phosphate
Guanosine
triphosphate
Guanosine
diphosphate
Carbon dioxide
Guanosine
triphosphate
Succinic acid
Coenzyme A
Guanosine
diphosphate
Phosphate
Carbon dioxide
S-
Acetyldihydrolipoamide-
E
Carbon dioxide
Quinone