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squalene
synthase 1
squalene
synthase 1
squalene
monooxygenase 1
Isomerase/Lyase
Isomerase/Lyase
beta-Chamigrene
synthase
(+)-alpha-
barbatene
synthase
Thujopsene
synthase
(Z)-gamma-
bisabolene
synthase 1
(S)-2,3-
Epoxysqualene
Farnesyl
pyrophosphate
PP
i
Presqualene
diphosphate
NADPH
H
+
PP
i
Squalene
NADP
O
2
H
2
O
PP
i
(+)-β-
Chamigrene
PP
i
(+)-α-barbatene
PP
i
(+)-Thujopsene
PP
i
γ-bisabolene
Magnesium
Magnesium
FAD
Magnesium
Magnesium
Magnesium
Magnesium
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
Chair-chair-
chair-chair
Triterpenoid
Chair-chair-
chair-boat
triterpenoid
Steroid
Biosynthesis
Terpenoid
Backbone
Biosynthesis
Endoplasmic Reticulum
Cytosol
Endoplasmic Reticulum
SQS1
SQS1
SQE1
Unknown
Unknown
AT5G44630
AT5G44630
AT5G44630
TPS12
(S)-2,3-
Epoxysqualene
Farnesyl
pyrophosphate
Pyrophosphate
Presqualene
diphosphate
NADPH
Hydrogen Ion
Pyrophosphate
Squalene
NADP
Oxygen
Water
Pyrophosphate
(+)-β-
Chamigrene
Pyrophosphate
(+)-α-barbatene
Pyrophosphate
(+)-Thujopsene
Pyrophosphate
γ-bisabolene
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
Chair-chair-
chair-chair
Triterpenoid
Chair-chair-
chair-boat
triterpenoid
Steroid
Biosynthesis
Terpenoid
Backbone
Biosynthesis
SQS1
SQS1
SQE1
AT5G44630
AT5G44630
AT5G44630
TPS12
S23O
FarPP
PP
i
Presqad
NADPH
H
+
PP
i
Squalen
NADP
O
2
H
2
O
PP
i
βC
PP
i
(+)aB
PP
i
Thujops
PP
i
gBsb
Mg2+
Mg2+
FAD
Mg2+
Mg2+
Mg2+
Mg2+
RNHR
ONHR
CCCCT
CCCBT
Ste Bio
PW122504
Endoplasmic Reticulum
Cytosol