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Pathway Description
Jasmonic Acid Biosynthesis
Arabidopsis thaliana
Category:
Metabolite Pathway
Sub-Category:
Signaling
Created: 2019-05-08
Last Updated: 2019-09-13
Jasmonic acid is an organic compound belonging to the family of jasmonates compounds found in many plants including jasmine. It functions as a phytohormone and is involved in many crucial physiological roles associated with plant growth and reproduction. Jasmonic acid is also commonly employed by plants as a defense mechanism. Jasmonic acid is synthesized from alpha-linoleic acid in a multi-step reaction in the chloroplast that yields dinor-12-oxo-phytodienoate (OPDA) before being transported onto the peroxisome where three enzymes -- acyl coenzyme A oxidase, OPC4-3-ketoacyl-CoA thiolase, and peroxisomal fatty acid beta-oxidation multifunctional protein A1M1 -- play important roles in the final synthesis alongside coenzyme A.
References
Jasmonic Acid Biosynthesis References
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Pubmed: 19716757
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Pubmed: 17085685
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Pubmed: 23518581
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Pubmed: 8290626
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Pubmed: 11130713
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Pubmed: 27862469
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Pubmed: 11130712
Robaglia C, Caranta C: Translation initiation factors: a weak link in plant RNA virus infection. Trends Plant Sci. 2006 Jan;11(1):40-5. doi: 10.1016/j.tplants.2005.11.004. Epub 2005 Dec 15.
Pubmed: 16343979
Laudert D, Pfannschmidt U, Lottspeich F, Hollander-Czytko H, Weiler EW: Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates. Plant Mol Biol. 1996 May;31(2):323-35. doi: 10.1007/bf00021793.
Pubmed: 8756596
Kubigsteltig I, Laudert D, Weiler EW: Structure and regulation of the Arabidopsis thaliana allene oxide synthase gene. Planta. 1999 Jun;208(4):463-71. doi: 10.1007/s004250050583.
Pubmed: 10420644
Nakamura Y, Sato S, Kaneko T, Kotani H, Asamizu E, Miyajima N, Tabata S: Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence features of the regions of 1,191,918 bp covered by seventeen physically assigned P1 clones. DNA Res. 1997 Dec 31;4(6):401-14. doi: 10.1093/dnares/4.6.401.
Pubmed: 9501997
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Pubmed: 12777050
Sato S, Nakamura Y, Kaneko T, Katoh T, Asamizu E, Tabata S: Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones. DNA Res. 2000 Apr 28;7(2):131-5. doi: 10.1093/dnares/7.2.131.
Pubmed: 10819329
Chini A, Monte I, Zamarreno AM, Hamberg M, Lassueur S, Reymond P, Weiss S, Stintzi A, Schaller A, Porzel A, Garcia-Mina JM, Solano R: An OPR3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis. Nat Chem Biol. 2018 Feb;14(2):171-178. doi: 10.1038/nchembio.2540. Epub 2018 Jan 1.
Pubmed: 29291349
Costa CL, Arruda P, Benedetti CE: An Arabidopsis gene induced by wounding functionally homologous to flavoprotein oxidoreductases. Plant Mol Biol. 2000 Sep;44(1):61-71. doi: 10.1023/a:1006464822434.
Pubmed: 11094980
Sanders PM, Lee PY, Biesgen C, Boone JD, Beals TP, Weiler EW, Goldberg RB: The arabidopsis DELAYED DEHISCENCE1 gene encodes an enzyme in the jasmonic acid synthesis pathway. Plant Cell. 2000 Jul;12(7):1041-61. doi: 10.1105/tpc.12.7.1041.
Pubmed: 10899973
Shockey JM, Fulda MS, Browse J: Arabidopsis contains a large superfamily of acyl-activating enzymes. Phylogenetic and biochemical analysis reveals a new class of acyl-coenzyme a synthetases. Plant Physiol. 2003 Jun;132(2):1065-76. doi: 10.1104/pp.103.020552.
Pubmed: 12805634
Koo AJ, Chung HS, Kobayashi Y, Howe GA: Identification of a peroxisomal acyl-activating enzyme involved in the biosynthesis of jasmonic acid in Arabidopsis. J Biol Chem. 2006 Nov 3;281(44):33511-20. doi: 10.1074/jbc.M607854200. Epub 2006 Sep 8.
Pubmed: 16963437
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Pubmed: 10571860
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Pubmed: 9461215
Mayer K, Schuller C, Wambutt R, Murphy G, Volckaert G, Pohl T, Dusterhoft A, Stiekema W, Entian KD, Terryn N, Harris B, Ansorge W, Brandt P, Grivell L, Rieger M, Weichselgartner M, de Simone V, Obermaier B, Mache R, Muller M, Kreis M, Delseny M, Puigdomenech P, Watson M, Schmidtheini T, Reichert B, Portatelle D, Perez-Alonso M, Boutry M, Bancroft I, Vos P, Hoheisel J, Zimmermann W, Wedler H, Ridley P, Langham SA, McCullagh B, Bilham L, Robben J, Van der Schueren J, Grymonprez B, Chuang YJ, Vandenbussche F, Braeken M, Weltjens I, Voet M, Bastiaens I, Aert R, Defoor E, Weitzenegger T, Bothe G, Ramsperger U, Hilbert H, Braun M, Holzer E, Brandt A, Peters S, van Staveren M, Dirske W, Mooijman P, Klein Lankhorst R, Rose M, Hauf J, Kotter P, Berneiser S, Hempel S, Feldpausch M, Lamberth S, Van den Daele H, De Keyser A, Buysshaert C, Gielen J, Villarroel R, De Clercq R, Van Montagu M, Rogers J, Cronin A, Quail M, Bray-Allen S, Clark L, Doggett J, Hall S, Kay M, Lennard N, McLay K, Mayes R, Pettett A, Rajandream MA, Lyne M, Benes V, Rechmann S, Borkova D, Blocker H, Scharfe M, Grimm M, Lohnert TH, Dose S, de Haan M, Maarse A, Schafer M, Muller-Auer S, Gabel C, Fuchs M, Fartmann B, Granderath K, Dauner D, Herzl A, Neumann S, Argiriou A, Vitale D, Liguori R, Piravandi E, Massenet O, Quigley F, Clabauld G, Mundlein A, Felber R, Schnabl S, Hiller R, Schmidt W, Lecharny A, Aubourg S, Chefdor F, Cooke R, Berger C, Montfort A, Casacuberta E, Gibbons T, Weber N, Vandenbol M, Bargues M, Terol J, Torres A, Perez-Perez A, Purnelle B, Bent E, Johnson S, Tacon D, Jesse T, Heijnen L, Schwarz S, Scholler P, Heber S, Francs P, Bielke C, Frishman D, Haase D, Lemcke K, Mewes HW, Stocker S, Zaccaria P, Bevan M, Wilson RK, de la Bastide M, Habermann K, Parnell L, Dedhia N, Gnoj L, Schutz K, Huang E, Spiegel L, Sehkon M, Murray J, Sheet P, Cordes M, Abu-Threideh J, Stoneking T, Kalicki J, Graves T, Harmon G, Edwards J, Latreille P, Courtney L, Cloud J, Abbott A, Scott K, Johnson D, Minx P, Bentley D, Fulton B, Miller N, Greco T, Kemp K, Kramer J, Fulton L, Mardis E, Dante M, Pepin K, Hillier L, Nelson J, Spieth J, Ryan E, Andrews S, Geisel C, Layman D, Du H, Ali J, Berghoff A, Jones K, Drone K, Cotton M, Joshu C, Antonoiu B, Zidanic M, Strong C, Sun H, Lamar B, Yordan C, Ma P, Zhong J, Preston R, Vil D, Shekher M, Matero A, Shah R, Swaby IK, O'Shaughnessy A, Rodriguez M, Hoffmann J, Till S, Granat S, Shohdy N, Hasegawa A, Hameed A, Lodhi M, Johnson A, Chen E, Marra M, Martienssen R, McCombie WR: Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature. 1999 Dec 16;402(6763):769-77. doi: 10.1038/47134.
Pubmed: 10617198
Richmond TA, Bleecker AB: A defect in beta-oxidation causes abnormal inflorescence development in Arabidopsis. Plant Cell. 1999 Oct;11(10):1911-24. doi: 10.1105/tpc.11.10.1911.
Pubmed: 10521521
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