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3-methyl-2-
oxobutanoate
hydroxymethyltransferase
2
Probable
2-dehydropantoate
2-reductase
Pantothenate
synthetase
pantothenate
kinase
Coenzyme A
biosynthesis
bifunctional
protein CoaBC
Coenzyme A
biosynthesis
bifunctional
protein CoaBC
Phosphopantetheine
adenylyltransferase
Dephospho-CoA
kinase
Probable 2-(5''-
triphosphoribosyl)-
3'-
dephosphocoenzyme-
A synthase
Dihydroxy-acid
dehydratase
Aspartate
1-decarboxylase
α-Ketoisovaleric
acid
L-Aspartic acid
5,10-Methylene-
THF
H
2
O
Tetrahydrofolic
acid
2-dehydropantoate
NADPH
H
+
NADP
(R)-pantoate
β-Alanine
ATP
AMP
PP
i
H
+
Pantothenic acid
ATP
ADP
H
+
D-4'-
Phosphopantothenate
Cytidine
triphosphate
L-Cysteine
Cytidine
monophosphate
PP
i
H
+
4'-
Phosphopantothenoylcysteine
H
+
CO
2
4'-
phosphopantetheine
ATP
H
+
PP
i
Dephospho-CoA
ATP
H
+
ADP
Coenzyme A
ATP
H
+
Adenine
2'-(5-
Triphosphoribosyl)-
3'-dephospho- CoA
2,3-
Dihydroxyisovaleric
acid
H
2
O
H
+
CO
2
Valine
Biosynthesis
Aspartate
Metabolism
Ketol-acid
reductoisomerase
(NADP(+))
panB2
panE
panC
rmlD
coaBC
coaBC
coaD
coaE
mdcB
ilvD
panD
α-Ketoisovaleric
acid
L-Aspartic acid
5,10-Methylene-
THF
Water
Tetrahydrofolic
acid
2-dehydropantoate
NADPH
Hydrogen Ion
NADP
(R)-pantoate
β-Alanine
Adenosine
triphosphate
Adenosine
monophosphate
Pyrophosphate
Hydrogen Ion
Pantothenic acid
Adenosine
triphosphate
Adenosine
diphosphate
Hydrogen Ion
D-4'-
Phosphopantothenate
Cytidine
triphosphate
L-Cysteine
Cytidine
monophosphate
Pyrophosphate
Hydrogen Ion
4'-
Phosphopantothenoylcysteine
Hydrogen Ion
Carbon dioxide
4'-
phosphopantetheine
Adenosine
triphosphate
Hydrogen Ion
Pyrophosphate
Dephospho-CoA
Adenosine
triphosphate
Hydrogen Ion
Adenosine
diphosphate
Coenzyme A
Adenosine
triphosphate
Hydrogen Ion
Adenine
2'-(5-
Triphosphoribosyl)-
3'-dephospho- CoA
2,3-
Dihydroxyisovaleric
acid
Water
Hydrogen Ion
Carbon dioxide
Valine
Biosynthesis
Aspartate
Metabolism
ilvC